Theta‐curves in proteins

Abstract

AbstractWe study and characterize the topology of connectivity circuits observed in natively folded protein structures whose coordinates are deposited in the Protein Data Bank (PDB). Polypeptide chains of some proteins naturally fold into unique knotted configurations. Another kind of nontrivial topology of polypeptide chains is observed when, in addition to covalent bonds connecting consecutive amino acids in polypeptide chains, one also considers disulfide and ionic bonds between non‐consecutive amino acids. Bonds between non‐consecutive amino acids introduce bifurcation points into connectivity circuits defined by bonds between consecutive and nonconsecutive amino acids in analyzed proteins. Circuits with bifurcation points can form θ‐curves with various topologies. We catalog here the observed topologies of θ‐curves passing through bridges between consecutive and non‐consecutive amino acids in studied proteins.