The Efficacy and Safety of Clazakizumab, an Anti-Interleukin-6 Monoclonal Antibody, in a Phase IIb Study of Adults With Active Psoriatic Arthritis

Author:

Mease Philip J.1,Gottlieb Alice B.2,Berman Alberto3,Drescher Edit4,Xing Jun5,Wong Robert5,Banerjee Subhashis5

Affiliation:

1. Swedish Medical Center and University of Washington; Seattle

2. Tufts Medical Center and Tufts University School of Medicine; Boston Massachusetts

3. Centro Médico Privado de Reumatología; Tucuman Argentina

4. Csolnoky Ferenc Hospital; Veszprém Hungary

5. Bristol-Myers Squibb; Princeton New Jersey

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Reference29 articles.

1. Interleukin-6 as a key player in systemic inflammation and joint destruction;Fonseca;Autoimmun Rev,2009

2. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes;Grossman;Proc Natl Acad Sci USA,1989

3. Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid;Partsch;J Rheumatol,1997

4. Interleukin-6 and soluble interleukin-2 receptor alpha-markers of inflammation in patients with psoriatic arthritis?;Alenius;Clin Exp Rheumatol,2009

5. Interleukin-6 and soluble interleukin-2-receptor in psoriatic arthritis: correlations with clinical and laboratory parameters;Spadaro;Clin Exp Rheumatol,1996

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