Implementation of QbD strategies in the inoculum expansion of a mAb production process

Author:

Böhl Ole Jacob1,Schellenberg Jana1,Bahnemann Janina1,Hitzmann Bernd2,Scheper Thomas1,Solle Dörte1

Affiliation:

1. Leibniz Universität Hannover Institut für Technische Chemie Hannover Germany

2. Universität Hohenheim Fachgebiet für Prozessanalytik und Getreidewissenschaft Stuttgart Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Bioengineering,Environmental Engineering,Biotechnology

Reference20 articles.

1. Quality by design for biopharmaceuticals

2. US Food and Drug Administration.Pharmaceutical cGMPs for the 21st Century—A risk‐based approach.2004.http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/Manufacturing/QuestionsandAnswersonCurrentGoodManufacturingPracticescGMPforDrugs/UCM176374.pdf.

3. Department of Health and Human Services Food and Drug Administration.PAT Guidance for Industry – A Framework for Innovative Pharmaceutical Development Manufacturing and Quality Assurance.2004.

4. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use.ICH harmonised tripartite guideline: Pharmaceutical development Q8(R2).2009.http://www.ich.org/fileadmin/PublicWebSite/ICHProducts/Guidelines/Quality/Q8R1/Step4/Q8R2Guideline.pdf.

5. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use.ICH harmonised tripartite guideline: Quality risk management (Q9).2005.http://www.ich.org/fileadmin/PublicWebSite/ICHProducts/Guidelines/Quality/Q9/Step4/Q9Guideline.pdf.

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