Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes-Reference-Cited by-同舟云学术

Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes

Published:2020-05-28 Issue:8 Volume:20 Page:368-378
ISSN:1618-0240
Container-title:Engineering in Life Sciences
language:en
Short-container-title:Eng. Life Sci.

Author:

Paul Katrin¹²^ORCID,Böttinger Katharina³⁴^ORCID,Mitic Bernd M.¹²,Scherfler Georg¹²,Posch Christoph⁵,Behrens Dirk⁵,Huber Christian G.³⁴,Herwig Christoph¹²

Affiliation:

1. Institute of Chemical Environmental and Bioscience Engineering TU Wien Vienna Austria

2. Christian Doppler Laboratory for Mechanistic and Physiological Methods for Improved Bioprocesses TU Wien Vienna Austria

3. Department of Biosciences Bioanalytical Research Labs University of Salzburg Salzburg Austria

4. Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization University of Salzburg Salzburg Austria

5. Sandoz GmbH Langkampfen Austria

Funder

Christian Doppler Forschungsgesellschaft

Publisher

Wiley

Subject

Bioengineering,Environmental Engineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/elsc.202000009

Reference46 articles.

1. The therapeutic monoclonal antibody market

2. Top drugs and companies by sales in 2017

3. Optimization and scale up of industrial fermentation processes

4. Scale-up analysis for a CHO cell culture process in large-scale bioreactors

5. Fed-batch bioreactor process scale-up from 3-L to 2,500-L scale for monoclonal antibody production from cell culture

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