Affiliation:
1. Key Laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for New Organic Matter College of Chemistry Nankai University Tianjin 300071 China
Abstract
AbstractPhotothermal therapy (PTT) systems typically do not possess intrinsic tumor‐targeting capability, resulting in indiscriminate thermal damage to both cancer and normal cells. Herein, a low‐density lipoprotein (LDL)‐based nanosystem (denoted as MTTQ@LDL) is reported for targeted photothermal killing of cancer cells. Such a nanosystem is fabricated by reconstituting the lipophilic core of LDL with an organic photothermal agent MTTQ. The reconstitution process improves the supramolecular photothermal effects of MTTQ assemblies, which contributes to the significantly enhanced photothermal conversion efficiency (41.3% vs. 16.2%). MTTQ@LDL can actively target LDL receptor‐overexpressed cancer cells via receptor‐mediated endocytosis, enabling the selective killing of cancer cells over normal cells (98% vs. 7%) post‐NIR irradiation. Reconstituted LDL can serve as a promising platform for targeted delivery of functional materials, holding great promise in tumor eradication in vivo.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
Materials Chemistry,Polymers and Plastics,Organic Chemistry
Cited by
1 articles.
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