A Temperature and pH Dual‐Sensitive Multifunctional Polyurethane with Bacteria‐Triggered Antibacterial Activity

Author:

Gao Qinwei12ORCID,Chen Zhaobin3ORCID,Yang Xiaoniu12ORCID

Affiliation:

1. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P.R. China

2. School of Applied Chemistry and Engineering, University of Science and Technology of China Hefei 230026 P.R. China

3. CAS Key Laboratory of High‐Performance Synthetic Rubber and Its Composite Materials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P.R. China

Abstract

AbstractAn effective and practical antibacterial strategy is to design multifunctional and stimuli‐responsive materials that exhibit antibacterial activity in response to bacterial triggers. In this study, because the metabolism of Staphylococcus aureus (S. aureus) can acidify the surrounding environment and pH level can affect the lower critical solution temperature of temperature/pH dual‐sensitive polymers, a monomer containing a temperature‐sensitive N‐isopropyl amide derivative and pH‐sensitive tertiary amine groups is first synthesized. Then, the monomer is copolymerized with a polyurethane chain, and partial tertiary amine groups are quaternized to obtain bactericidal activity. The modified polyurethane exhibits temperature/pH sensitivity, antibacterial adhesion activity, bactericidal activity, and good cytocompatibility. An in situ investigation of bacterial behavior and pH changes in the bacterial suspension during the process confirms that the temperature/pH dual‐sensitive polyurethane successfully achieves antibacterial activity though the metabolic activity of S. aureus without external intervention. This design concept provides a new perspective for antibacterial material design.

Publisher

Wiley

Subject

Materials Chemistry,Polymers and Plastics,Organic Chemistry

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