Affiliation:
1. Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China
2. University of Chinese Academy of Sciences Beijing 100049 China
3. Xihua University Chengdu 610041 China
Abstract
AbstractPhotothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near‐infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo‐based dual‐acceptor conjugated polymers (CPs) (P‐IIG‐TPD, P‐IIG‐DPP, and P‐IIG‐EDOT‐BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P‐IIG‐EDOT‐BT and P‐IIG‐DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P‐IIG‐EDOT‐BT and P‐IIG‐DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual‐acceptor CPs for tumor diagnosis and treatment.
Subject
Materials Chemistry,Polymers and Plastics,Organic Chemistry
Cited by
2 articles.
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