The effect of Xylocaine spray on suture material degradation

Author:

Jannati Pantea1ORCID,Sørensen Charlotte Arp2,Gommesen Ditte3,Glavind‐Kristensen Marianne4,Seehafer Peggy5,Kindberg Sara Fevre6,Hjorth Sarah78

Affiliation:

1. Hospital Pharmacy Central Denmark Region, Clinical Pharmacy Aarhus University Hospital Aarhus N Denmark

2. Hospital Pharmacy Central Denmark Region, Research & Development Department and Clinical Pharmacy Aarhus University Hospital Aarhus N Denmark

3. Institute of Clinical Research, University of Southern Denmark Odense Denmark

4. Department of Gynecology and Obstetrics Aarhus University Hospital Aarhus N Denmark

5. AnthropologenKontor Hamburg Germany

6. GynZone Denmark Aarhus C Denmark

7. Department of Gynecology and Obstetrics Odense University Hospital Odense Denmark

8. Research Unit for Gynecology and Obstetrics, Department of Clinical Research University of Southern Denmark Odense Denmark

Abstract

AbstractObjectivesTo compare the tensile strength of fast absorbable Polyglactin 910 suture material when impregnated with various agents for local anesthesia and to investigate whether the presence of ethanol in Xylocaine spray could explain a potential reduction in tensile strength after use of Xylocaine spray.MethodsIn all, 120 suture samples of Polyglactin 910 were divided into four groups of 30. These four groups were randomly impregnated with isotonic sodium chloride, isotonic sodium chloride plus Xylocaine spray, isotonic sodium chloride plus Xylocaine gel, or isotonic sodium chloride plus ethanol. After impregnation, the sutures were stored in sealed glass tubes in a heating cabinet at 37°C for 72 h. Thereafter, the tensile strength of these 120 samples was assessed by a universal tensile testing machine. The maximal force needed to break the suture material was recorded in newtons (N).ResultsFast absorbable Polyglactin 910 suture material impregnated with Xylocaine spray or ethanol showed weakened tensile strength (mean values 11.40 and 11.86 N, respectively), whereas the specimens impregnated with Xylocaine gel or sodium chloride retained their tensile strength better (mean values 13.81 and 13.28 N, respectively; mean difference between Xylocaine gel and Xylocaine spray −2.41 N, P < 0.001).ConclusionIn this in vitro experiment, ethanol and Xylocaine spray weakened the tensile strength of fast absorbable Polyglactin 910 sutures. Use of Xylocaine spray, which contains ethanol, for local anesthesia might lead to early breakdown of the suture material and wound rupture. The authors suggest caution when using Xylocaine spray in combination with fast absorbable Polyglactin 910 suture.

Publisher

Wiley

Subject

Obstetrics and Gynecology,General Medicine

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