Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very highTP53mutation frequency of 93%-Reference-Cited by-同舟云学术

Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very highTP53mutation frequency of 93%

Published:2014-03-11 Issue:6 Volume:53 Page:524-536
ISSN:1045-2257
Container-title:Genes, Chromosomes and Cancer
language:en
Short-container-title:Genes Chromosomes Cancer

Author:

Mühlbacher Verena¹,Zenger Melanie¹,Schnittger Susanne¹,Weissmann Sandra¹,Kunze Franziska¹,Kohlmann Alexander¹,Bellos Frauke¹,Kern Wolfgang¹,Haferlach Torsten¹,Haferlach Claudia¹

Affiliation:

1. MLL Munich Leukemia Laboratory; Munich Germany

Publisher

Wiley

Subject

Cancer Research,Genetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/gcc.22163/fullpdf

Reference36 articles.

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3. A report from the LALA-94 and LALA-SA groups on hypodiploidy with 30 to 39 chromosomes and near-triploidy: 2 possible expressions of a sole entity conferring poor prognosis in adult acute lymphoblastic leukemia (ALL);Charrin;Blood,2004

4. TP53 mutations are frequent in adult acute lymphoblastic leukemia cases negative for recurrent fusion genes and correlate with poor response to induction therapy;Chiaretti;Haematologica,2013

5. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia;Faderl;Blood,1998

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