Affiliation:
1. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing China
2. Materials Science and Engineering Beijing University of Chemical Technology Beijing China
3. Tangdu Hospital Air Force Medical University Xi'an China
4. Life Sciences Institute Zhejiang University Hangzhou China
5. University of Chinese Academy of Sciences Beijing China
Abstract
AbstractNanoparticle‐based vaccines offer a multivalent approach for antigen display, efficiently activating T and B cells in the lymph nodes. Among various nanoparticle design strategies, DNA nanotechnology offers an innovative alternative platform, featuring high modularity, spatial addressing, nanoscale regulation, high functional group density, and lower self‐antigenicity. This review delves into the potential of DNA nanostructures as biomolecular scaffolds for antigen display, addressing: (1) immunological mechanisms behind nanovaccines and commonly used nanoparticles in their design, (2) techniques for characterizing protein NP–antigen complexes, (3) advancements in DNA nanotechnology and DNA–protein assembly approach, (4) strategies for precise antigen presentation on DNA scaffolds, and (5) current applications and future possibilities of DNA scaffolds in antigen display. This analysis aims to highlight the transformative potential of DNA nanoscaffolds in immunology and vaccinology.This article is categorized under:
Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures
Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Biomedical Engineering,Medicine (miscellaneous),Bioengineering