MR Diffusion Kurtosis Imaging (DKI) of the Normal Human Uterus in Vivo During the Menstrual Cycle

Author:

Li Yajie12,Chen Ye1,Fu Caixia3,Li Qing4,Liu Hanqiu12,Zhang Qi1ORCID

Affiliation:

1. Department of Radiology, Huashan Hospital Fudan University Shanghai China

2. Shanghai Institute of Medical Imaging Shanghai China

3. MR Application Development Siemens Shenzhen Magnetic Resonance Ltd Shenzhen China

4. MR Collaborations Siemens Healthineers Digital Technology (Shanghai) Co., Ltd. Shanghai China

Abstract

BackgroundThe uterus undergoes dynamic changes throughout the menstrual cycle. Diffusion kurtosis imaging (DKI) is based on the non‐Gaussian distribution of water molecules and can perhaps represent the changes of uterine microstructure.PurposeTo investigate the temporal changes in DKI‐parameters of the normal uterine corpus and cervix during the menstrual cycle.Study TypeProspective.Population21 healthy female volunteers (26.64 ± 4.72 years) with regular menstrual cycles (28 ± 7 days).Field Strength/SequenceReadout segmentation of long variable echo‐trains (RESOLVE)‐based DKI and fast spin‐echo T2‐weighted sequences at 3.0T.AssessmentEach volunteer was scanned during the menstrual phase, ovulatory phase, and luteal phase. Regions of interest (ROI) were manually delineated in the endometrium, junctional zone, and myometrium of the uterine body, and in the mucosal layer, fibrous stroma layer, and loose stroma layer of the cervix. The mean Kapp (diffusion kurtosis coefficient), Dapp (diffusion coefficient), and ADC (apparent diffusion coefficient) values were measured in the ROI.Statistical TestsANOVA with Bonferroni or Tamhane correction. Intraclass correlation coefficient (ICC) for assessing agreement. P < 0.05 was considered statistically significant.ResultsDuring the menstrual cycle, the highest Kapp (0.848 ± 0.184) and lowest Dapp (1.263 ± 0.283 *10−3 mm2/sec) values were found in the endometrium during the menstrual phase. The Dapp values for the myometrium were significantly higher than those of the endometrium and the junctional zone in every phase. Meanwhile, the Dapp values for the three zonal structures of the cervix during ovulation were significantly higher than those during the luteal phase. However, there was no significant difference in the ADC values of the loose stroma between ovulation and the luteal phase (P = 0.568). The reproducibility of DKI parameters was good (ICC, 0.857–0.944).Data ConclusionDKI can show dynamic changes of the normal uterus during the menstrual cycle.Level of Evidence2Technical EfficacyStage 2

Funder

Shanghai Municipal Health Commission

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3