Assessment of Pulmonary Ventilation Using 3D Ventilation Flow‐Weighted and Ventilation‐Weighted Maps From 3D Ultrashort Echo Time (UTE) MRI

Abstract

BackgroundThree‐dimensional (3D) ventilation flow‐weighted (VFW) maps together with 3D ventilation‐weighted (VW) maps may help to better assess pulmonary function.PurposeTo investigate the use of 3D VFW and VW maps for evaluating pulmonary ventilation function.Study TypeProspective.PopulationTwo patients (one male, 85 years old; one female, 64 years old) with chronic obstructive pulmonary disease (COPD) and nine healthy subjects (all male; 23–27 years).Field Strength/Sequence3‐T, 3D radial UTE imaging.Assessment3D VFW and VW maps were calculated from 3D UTE MRI by voxel‐wise subtraction of respiratory phase images. Their validation was tested in nine healthy volunteers using slow/deep and fast/shallow breathing conditions. Additional validation was performed by comparison with single photon emission computed tomography (SPECT) ventilation maps of one healthy participant. For comparison, gravity dependence of anterior–posterior regional ventilation was assessed by one‐dimensional plot of the mean signal intensity for each coronal slice. Structural similarity index measure was also calculated. Finally, VW maps and VFW maps of two COPD patients were evaluated for emphysema lesions with reference to CT images.Statistical TestsWilcoxon sign‐rank tests for regional Ventilation and Ventilation flow, analysis of variance, post‐hoc t‐tests and Bonferroni correction, coefficient of variation, Kullback–Liebler divergence. A P‐value <0.05 was considered statistically significant.ResultsThe validation of 3D VFW and VW maps was shown by statistically significant differences in ventilation flow and ventilation between the breathing conditions. Additionally, UTE‐MRI and SPECT‐based ventilation maps showed gravitational dependence in the anteroposterior direction. When applied to patients with COPD, the use of 3D VFW and VW maps was able to differentiate between two patients with different phenotypes.Data ConclusionThe use of 3D VFW and VW maps can provide regional information on ventilation function and potentially contribute to assessment of COPD subtypes and disease progression.Evidence Level2Technical EfficacyStage 1