Where does O6 -methylguanine DNA methyltransferase promoter methylation assessment place temozolomide in the future standards of care for glioblastoma?
Author:
Affiliation:
1. Department of Neurology; University Hospital and University of Zurich; Zurich Switzerland
Funder
Actelion
Acceleron
Bayer
OGD2 Pharma
Piqur
Tragara
Abbvie
MSD
Merck
Novocure
Roche
Bristol-Myers Squibb
Celgene
Celldex
Orbus
Pfizer
Progenics
Teva
Tocagen
Publisher
Wiley
Subject
Cancer Research,Oncology
Reference19 articles.
1. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine;Belanich;Cancer Res.,1996
2. Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study;Jaeckle;J Clin Oncol.,1998
3. DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma;Friedman;J Clin Oncol.,1998
4. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents;Esteller;N Engl J Med.,2000
5. Clinical trial substantiates the predictive value of O6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide;Hegi;Clin Cancer Res.,2004
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