Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: GermlineBRCAmutation carriers and wild-typeBRCApancreatic ductal adenocarcinoma

Author:

O'Reilly Eileen M.12ORCID,Lee Jonathan W.1,Lowery Maeve A.1,Capanu Marinela1,Stadler Zsofia K.12,Moore Malcolm J.3,Dhani Neesha3,Kindler Hedy L.4,Estrella Hayley1,Maynard Hannah1,Golan Talia56,Segal Amiel7,Salo-Mullen Erin E.1,Yu Kenneth H.12,Epstein Andrew S.12,Segal Michal1,Brenner Robin1,Do Richard K.12,Chen Alice P.8,Tang Laura H.12,Kelsen David P.12

Affiliation:

1. Memorial Sloan Kettering Cancer Center; New York New York

2. Weill Cornell Medicine; New York New York

3. Princess Margaret Cancer Centre; University Health Network; Toronto Ontario Canada

4. University of Chicago Medical Center; Chicago Illinois

5. Sheba Medical Center; Tel Hashomer Israel

6. Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel

7. Share Zedek Medical Center; Jerusalem Israel

8. National Cancer Institute; Bethesda Maryland

Funder

Lustgarten Foundation

David M. Rubenstein Center for Pancreatic Cancer Research

National Cancer Institute

Cancer Center Support

National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference37 articles.

1. Cancer statistics, 2016;Siegel;CA Cancer J Clin.,2016

2. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010;Sun;Sci Rep.,2014

3. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer;Conroy;N Engl J Med.,2011

4. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine;Hoff;N Engl J Med.,2013

5. BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian;Friedenson;MedGenMed.,2005

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