Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 ( DE3 )-Reference-Cited by-同舟云学术

Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 ( DE3 )

Published:2021-03-11 Issue:9 Volume:3 Page:
ISSN:2577-8196
Container-title:Engineering Reports
language:en
Short-container-title:Engineering Reports

Author:

Li Zhaopeng¹,Geffers Robert²,Jain Garima¹³,Klawonn Frank²⁴,Kökpinar Öznur¹⁵,Nimtz Manfred²,Schmidt‐Heck Wolfgang⁶,Rinas Ursula¹²^ORCID

Affiliation:

1. Leibniz University of Hannover, Technical Chemistry – Life Science Hannover Germany

2. Helmholtz Centre for Infection Research Braunschweig Germany

3. Department of Biotechnology Indian Institute of Technology Madras Chennai India

4. Ostfalia University of Applied Science Wolfenbüttel Germany

5. Faculty of Pharmacy Adıyaman University Adıyaman Turkey

6. Leibniz Institute for Natural Product Research and Infection Biology – Hans‐Knöll‐Institute Jena Germany

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Deutscher Akademischer Austauschdienst

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/eng2.12393

Reference88 articles.

1. Recombinant protein production‐associated metabolic burden reflects anabolic constraints and reveals similarities to a carbon overfeeding response

2. Recombinant protein production associated growth inhibition results mainly from transcription and not from translation

3. Codon usage influences fitness through RNA toxicity

4. Minimizing inclusion body formation during recombinant protein production in Escherichia coli at bench and pilot plant scale

5. Global proteome response ofEscherichia coliBL21 to production of human basic fibroblast growth factor in complex and defined medium

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4. Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess;Microbial Cell Factories;2022-04-21

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