Lack of clinically important PK interaction between coformulated ledipasvir/sofosbuvir and rilpivirine/emtricitabine/tenofovir alafenamide

Author:

Custodio Joseph M.1,Chuck Susan K.1,Chu Hoa1ORCID,Cao Huyen1,Ma Grace1,Flaherty John1,Ling John1,Kearney Brian P.1

Affiliation:

1. Gilead Sciences; 333 Lakeside Drive Foster City California 94404

Funder

Gilead Sciences

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference29 articles.

1. American Association for the Study of Liver Diseases 2017 Unique patient populations: patients with HIV/HCV coinfection http://www.hcvguidelines.org/full-report/unique-patient-populations-patients-hivhcv-coinfection

2. Nephrotoxicity associated with concomitant use of ledipasvir-sofosbuvir and tenofovir in a patient with hepatitis C Virus and human immunodeficiency virus coinfection;Bunnell;Pharmacotherapy,2016

3. Centers for Disease Control and Prevention 2017 Viral hepatitis - CDC recommendations for specific populations and settings http://www.cdc.gov/hepatitis/populations/hiv.htm

4. Meta-analysis: increased mortality associated with hepatitis C in HIV-infected persons is unrelated to HIV disease progression;Chen;Clin Infect Dis,2009

5. Custodio JM Doyle EB Pang PS Das M Cao H Ma G 2015 Lack of drug interactions between boosted and unboosted TAF-based antiretroviral single-tablet regimens (E/C/F/TAF, R/F/TAF) and the anti-HCV single-tablet regimen ledipasvir/sofosbuvir

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