Associations of visual, hearing, and dual sensory impairment with motoric cognitive risk syndrome: Observational and Mendelian randomization analyses

Author:

Liang Haixu12ORCID,Liang Yinhao12,Zheng Yixuan12,Fang Ya12ORCID

Affiliation:

1. School of Public Health Xiamen University Xiamen China

2. Key Laboratory of Health Technology Assessment of Fujian Province University Xiamen University Xiamen China

Abstract

AbstractBackgroundDementia is associated with individual vision impairment (VI) and hearing impairment (HI). However, little is known about their associations with motoric cognitive risk syndrome (MCR), a pre‐dementia stage. We investigated the association of VI, HI, and dual sensory impairment (DSI) with MCR and to further evaluate causal relationships using Mendelian randomization (MR) approach.MethodsFirst, an observational study was conducted in the China Health and Retirement Longitudinal Study (CHARLS). Evaluate the cross‐sectional and longitudinal associations of VI, HI, and DSI with MCR using the logistic regression models and Cox proportional hazard models, respectively. Second, evaluate the causal association between VI and HI with MCR using MR analysis. The GWAS data was used for genetic instruments, including 88,250 of European ancestry (43,877 cases and 44,373 controls) and 504,307 with “white British” ancestry (100,234 cases and 404,073 controls), respectively; MCR information was obtained from the GWAS with 22,593 individuals. Inverse variance weighted was the primary method and sensitivity analysis was used to evaluate the robustness of MR methods.ResultsIn the observational study, VI (HR: 1.767, 95%CI: 1.331–2.346; p < 0.001), HI (HR: 1.461, 95%CI: 1.196–1.783; p < 0.001), and DSI (HR: 1.507, 95%CI: 1.245–1.823; p < 0.001) were significantly associated with increased risk of MCR. For the MR, no causal relationship between VI (OR: 0.902, 95% CI: 0.593–1.372; p = 0.631) and HI (OR: 1.016, 95% CI: 0.989–1.043; p = 0.248) with MCR risk, which is consistent with the sensitivity analysis.ConclusionVI, HI, and DSI were significantly associated with MCR, but MR analysis failed to provide evidence of their causal relationship. Emphasized the importance of sensory impairment screening in identifying high‐risk populations for dementia.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3