Author:
Ghorai Manas K.,Halder Sandipan,Samanta Sauvik
Abstract
The carboamination reaction can be considered an important and fascinating tool for atom‐economic and convergent construction toward the functionalizedN‐containing cyclic compounds. Because the aza‐cycle is frequently found in almost all members of the alkaloid family with immense synthetic and pharmacological activities, the formation of this ring system is a highly demanding task for synthetic organic chemists. As a result, several rational techniques have been developed including intramolecular SN2 reactions, reductive amination reactions, conjugate addition reactions, metal‐ and acid‐catalyzed cyclizations, and ring‐closing olefin metathesis reactions. Despite the many available routes, the carboamination strategy could be one of the best techniques considering stereoselectivity and the step economic path toward the formation of ring compounds in an elegant way.Alkylative cyclization with CN bond formation (N‐alkylation) is one of the most important methods in organic synthesis for the construction of aza‐cycles. Many well‐known name reactions (e.g., aza‐Diels‐Alder, aza‐Michael, aza‐Mannich, aza‐Henry reactions, etc.), which are generally being employed in the intramolecular CN bond formation step, can be treated as CN alkylative cyclization. It is an extremely powerful method for the stereoselective synthesis ofN‐heterocycles like aziridines, azetidines, lactams, pyrrolidines, piperidines, amino sugars, and many more, which are the basic structural units present in many natural products and biologically active compounds.