Author:
Murphy Cormac D.,Clark Benjamin R.
Abstract
Halogenation of biologically active compounds is an attractive method for moderating their properties. Although there are numerous synthetic methodologies for halogen incorporation, biological alternatives are attractive because of the characteristics of enzyme‐catalyzed reactions, such as mild conditions of temperature and pH, and the avoidance of noxious reagents. In recent years, our understanding of the enzymology of halogenation has increased dramatically, and several new classes of enzymes catalyzing electrophilic, nucleophilic, and free radical halogenations have been identified. Furthermore, advances in molecular biology and genome sequencing have widened the possibilities of employing microorganisms to elaborate novel halogenated compounds with valuable medicinal properties.