Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves

Author:

Backhausen Lea L.12ORCID,Fröhner Juliane H.1,Lemaître Hervé34,Artiges Eric56,Martinot Marie‐Laure Palillère57,Herting Megan M.8ORCID,Sticca Fabio9,Banaschewski Tobias10,Barker Gareth J.11,Bokde Arun L. W.12,Desrivières Sylvane13,Flor Herta1415,Grigis Antoine3,Garavan Hugh16,Gowland Penny17,Heinz Andreas18,Brühl Rüdiger19,Nees Frauke101420,Papadopoulos‐Orfanos Dimitri3,Poustka Luise21,Hohmann Sarah1022,Robinson Lauren23,Walter Henrik18,Winterer Jeanne1824,Whelan Robert25,Schumann Gunter132627,Martinot Jean‐Luc5,Smolka Michael N.1ORCID,Vetter Nora C.1228ORCID,

Affiliation:

1. Department of Psychiatry and Psychotherapy TUD Dresden University of Technology Dresden Germany

2. Department of Child and Adolescent Psychiatry, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology Dresden Germany

3. NeuroSpin, CEA Université Paris‐Saclay Gif‐sur‐Yvette France

4. Institut des Maladies Neurodégénératives, UMR 5293, CNRS, CEA Université de Bordeaux Bordeaux France

5. Institut National de la Santé et de la Recherche Médicale, INSERM U1299 "Trajectoires Développementales en Psychiatrie" Université Paris‐Saclay, Ecole Normale supérieure Paris‐Saclay, CNRS, Centre Borelli Gif‐sur‐Yvette France

6. Department of Psychiatry Lab‐D‐Psy, EPS Barthélémy Durand Etampes France

7. AP‐HP, Sorbonne Université, Department of Child and Adolescent Psychiatry Pitié‐Salpêtrière Hospital Paris France

8. Departments of Population and Public Health Sciences and Pediatrics University of Southern California Los Angeles California USA

9. Institute for Educational Support for Behaviour, Social‐Emotional, and Psychomotor Development University of Teacher Education in Special Needs Zurich Switzerland

10. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University Mannheim Germany

11. Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK

12. Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience Trinity College Dublin Dublin Ireland

13. Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre King's College London London UK

14. Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University Mannheim Germany

15. Department of Psychology, School of Social Sciences University of Mannheim Mannheim Germany

16. Departments of Psychiatry and Psychology University of Vermont Burlington Vermont USA

17. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham, University Park Nottingham UK

18. Department of Psychiatry and Neurosciences Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, and Berlin Institute of Health Berlin Germany

19. Physikalisch‐Technische Bundesanstalt (PTB) Braunschweig Germany

20. Institute of Medical Psychology and Medical Sociology University Medical Center Schleswig Holstein, Kiel University Kiel Germany

21. Department of Child and Adolescent Psychiatry and Psychotherapy University Medical Centre Göttingen Göttingen Germany

22. Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics University Medical Center Hamburg Eppendorf Hamburg Germany

23. Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry Psychology and Neuroscience, King's College London London UK

24. Department of Education and Psychology Freie Universität Berlin Berlin Germany

25. School of Psychology and Global Brain Health Institute Trinity College Dublin Dublin Ireland

26. PONS Research Group, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte Humboldt University, Berlin and Leibniz Institute for Neurobiology Magdeburg Germany

27. Institute for Science and Technology of Brain‐Inspired Intelligence (ISTBI) Fudan University Shanghai China

28. Department of Psychology MSB Medical School Berlin Berlin Germany

Abstract

AbstractAdolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software, and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age‐related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.

Funder

National Institutes of Health

Bundesministerium für Bildung und Forschung

Agence Nationale de la Recherche

Fondation de France

Fondation pour la Recherche Médicale

Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives

Fondation de l'Avenir pour la Recherche Médicale Appliquée

Fédération pour la Recherche sur le Cerveau

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Influence of Maternal and Paternal Parenting on Adolescent Brain Structure;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging;2024-07

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3