Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction

Abstract

AbstractAs an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature‐triggered multilayer capsule with chitosan‐sodium dodecyl benzene sulfonate (CS‐SDBS) as the shell and gelatin bead containing α‐cyclodextrin (α‐CD@gelatin) as the core. The α‐CD@gelatin/CS‐SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature‐sensitive property of gelatin and the host‐guest interaction between α‐CD and SDBS are utilized to achieve temperature‐controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α‐CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α‐CD@gelatin/CS‐SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug‐controlled release, and chemical detection.