Aortic valve fenestrations: Macroscopic assessment and functional anatomy study

Author:

Dudkiewicz Damian1,Zhingre Sanchez Jorge D.2,Hołda Jakub1,Bolechała Filip3,Strona Marcin3,Kopacz Paweł3,Iaizzo Paul A.2ORCID,Koziej Mateusz1ORCID,Hołda Mateusz K.145ORCID,Konieczyńska Małgorzata46

Affiliation:

1. HEART ‐ Heart Embryology and Anatomy Research Team, Department of Anatomy Jagiellonian University Medical College Cracow Poland

2. Visible Heart® Laboratories, Departments of Biomedical Engineering and Surgery, Institute for Engineering in Medicine University of Minnesota Minneapolis Minnesota USA

3. Department of Forensic Medicine Jagiellonian University Medical College Cracow Poland

4. Department of Diagnostic Medicine John Paul II Hospital Kraków Poland

5. Division of Cardiovascular Sciences The University of Manchester Manchester UK

6. Department of Thromboembolic Diseases Jagiellonian University Medical College Cracow Poland

Abstract

AbstractAortic valve fenestrations are defined as a loss of aortic valve leaflet tissue. They are a common but overlooked finding with unclear significance. The aim of this study was to investigate the varied functional anatomies of aortic valve fenestrations. A total of 400 formalin‐fixed autopsied human hearts were macroscopically assessed and the function of the aortic valve of 16 reanimated human hearts were imaged using Visible Heart® methodologies. Aortic valve leaflet fenestrations were present in 43.0% of autopsied hearts (in one leaflet in 24.0%, in two leaflets 16.0%, in all leaflets 3.0%). Fenestrations were mostly present in left (25.5%) followed by right (23.3%) and noncoronary leaflet (16.3%). In 93.8% of cases, the fenestrations form clusters and were mainly located at the free edge of the leaflet in the commissural area (95.4%). Hearts with aortic valve fenestrations had significantly larger aortic valve diameters and aortic valve areas (p < 0.001). The average surface area sizes of fenestrations were 23.8 ± 16.6 mm2, and the areas were largest for left followed by right and noncoronary leaflet fenestrations (p < 0.001). The fenestration areas positively correlated with donor age (r = 0.31; p = 0.02). Significant hypermobility and subjective weakening of the leaflet adhesion levels of the fenestrated regions were observed. In conclusion, fenestrations of the aortic leaflets are frequent, and their sizes may be significant. They occur in all age groups, yet their size increase with aging. Fragments of leaflets with fenestrations show different behaviors during the cardiac cycle versus unchanged areas.

Funder

Narodowe Centrum Badań i Rozwoju

Publisher

Wiley

Subject

General Medicine,Histology,Anatomy

Reference28 articles.

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