Lactase for infantile colic: A systematic review of randomized clinical trials

Author:

Nau Angélica Luciana1ORCID,Bassan Amanda Santiago2,Cezar Alessandra Bacelar3,de Carlos Gabriel Assis4,Deboni Mariana5

Affiliation:

1. Division of Pediatric Gastroenterology Hospital Jaraguá Jaraguá do Sul Brazil

2. Universidade Municipal de São Caetano do Sul São Caetano do Sul Brazil

3. Universidade Católica de Brasília Brasilia Brazil

4. Homer Stryker School of Medicine Western Michigan University Kalamazoo Michigan USA

5. Faculdade de Medicina da Universidade de São Paulo São Paulo Brazil

Abstract

AbstractInfantile colic is excessive crying for no apparent reason in an otherwise healthy infant. Although its physiopathology is not completely understood, therapies usually target gastrointestinal symptoms. This systematic review of randomized controlled trials (RCTs) analyzes the efficacy of lactase supplementation in infantile colic. PubMed, Embase, and Cochrane were searched for RCTs evaluating lactase supplementation in infants up to 6 months old with infantile colic. Out of six RCTs including 394 patients, three reported a significantly shorter crying time in the lactase group than in the placebo group, while the other three found no significant difference between groups. Of the two studies that performed the hydrogen breath test, only one reported a significant reduction in exhaled hydrogen levels. The pharmacological approach to infantile colic remains debatable, and new studies with standardized diagnostic criteria and outcomes are required to guide lactase supplementation in clinical practice.

Publisher

Wiley

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