Methionine oxidation of CLK4 promotes the metabolic switch and redox homeostasis in esophageal carcinoma via inhibiting MITF selective autophagy

Author:

Shen Yaxing12,Zhang Heng3,Yao Shihua4,Su Feng1,Wang Hao1,Yin Jun1,Fang Yong1,Tan Lijie1,Zhang Kaiguang5,Fan Xiangshan6,Zhong Ming7,Zhou Qingxin8,He Jie2,Zhang Zhiyong910ORCID

Affiliation:

1. Department of Thoracic Surgery Zhongshan Hospital, Fudan University Shanghai China

2. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

3. Department of Histology and Embryology Xiang Ya School of Medicine, Central South University Changsha China

4. Department of Thoracic Surgery Navy Military Medical University Affiliated Changhai Hospital Shanghai China

5. Department of Digestive Disease The First Affiliated Hospital of USTC (Anhui Provincial Hospital) Hefei China

6. Department of Pathology The affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing China

7. Department of Critical Care Medicine Zhongshan Hospital, Fudan University Shanghai China

8. Department of Gastrointestinal Oncology Harbin Medical University Cancer Hospital Harbin China

9. National Center for International Research of Biological Targeting Diagnosis and Therapy (Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research) Guangxi Medical University Nanning China

10. Department of Surgery, Robert‐Wood‐Johnson Medical School University Hospital Rutgers University, State University of New Jersey New Brunswick New Jersey USA

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

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