The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020)

Author:

Egi Moritoki1,Ogura Hiroshi2,Yatabe Tomoaki3,Atagi Kazuaki4,Inoue Shigeaki5,Iba Toshiaki6,Kakihana Yasuyuki7,Kawasaki Tatsuya8,Kushimoto Shigeki9,Kuroda Yasuhiro10,Kotani Joji11,Shime Nobuaki12,Taniguchi Takumi13,Tsuruta Ryosuke14,Doi Kent15,Doi Matsuyuki16,Nakada Taka‐aki17,Nakane Masaki18,Fujishima Seitaro19,Hosokawa Naoto20,Masuda Yoshiki21,Matsushima Asako22,Matsuda Naoyuki23,Yamakawa Kazuma24,Hara Yoshitaka3,Sakuraya Masaaki25,Ohshimo Shinichiro12,Aoki Yoshitaka16,Inada Mai26,Umemura Yutaka27,Kawai Yusuke28,Kondo Yutaka29,Saito Hiroki30,Taito Shunsuke31,Takeda Chikashi32,Terayama Takero33,Tohira Hideo34,Hashimoto Hideki35,Hayashida Kei36,Hifumi Toru37,Hirose Tomoya38,Fukuda Tatsuma39,Fujii Tomoko40,Miura Shinya41,Yasuda Hideto42,Abe Toshikazu43,Andoh Kohkichi44,Iida Yuki45,Ishihara Tadashi29,Ide Kentaro46,Ito Kenta47,Ito Yusuke48,Inata Yu49,Utsunomiya Akemi50,Unoki Takeshi51,Endo Koji52,Ouchi Akira53,Ozaki Masayuki54,Ono Satoshi55,Katsura Morihiro56,Kawaguchi Atsushi57,Kawamura Yusuke58,Kudo Daisuke9,Kubo Kenji59,Kurahashi Kiyoyasu60,Sakuramoto Hideaki53,Shimoyama Akira42,Suzuki Takeshi61,Sekine Shusuke62,Sekino Motohiro63,Takahashi Nozomi17,Takahashi Sei64,Takahashi Hiroshi65,Tagami Takashi66,Tajima Goro67,Tatsumi Hiroomi21,Tani Masanori68,Tsuchiya Asuka69,Tsutsumi Yusuke69,Naito Takaki70,Nagae Masaharu71,Nagasawa Ichiro72,Nakamura Kensuke73,Nishimura Tetsuro74,Nunomiya Shin75,Norisue Yasuhiro76,Hashimoto Satoru77,Hasegawa Daisuke3,Hatakeyama Junji78,Hara Naoki79,Higashibeppu Naoki80,Furushima Nana81,Furusono Hirotaka82,Matsuishi Yujiro83,Matsuyama Tasuku84,Minematsu Yusuke85,Miyashita Ryoichi86,Miyatake Yuji87,Moriyasu Megumi88,Yamada Toru89,Yamada Hiroyuki90,Yamamoto Ryo91,Yoshida Takeshi92,Yoshida Yuhei93,Yoshimura Jumpei27,Yotsumoto Ryuichi94,Yonekura Hiroshi95,Wada Takeshi96,Watanabe Eizo97,Aoki Makoto98,Asai Hideki99,Abe Takakuni100,Igarashi Yutaka101,Iguchi Naoya102,Ishikawa Masami103,Ishimaru Go104,Isokawa Shutaro37,Itakura Ryuta105,Imahase Hisashi106,Imura Haruki107108,Irinoda Takashi109,Uehara Kenji110,Ushio Noritaka111,Umegaki Takeshi112,Egawa Yuko113,Enomoto Yuki114,Ota Kohei12,Ohchi Yoshifumi100,Ohno Takanori115,Ohbe Hiroyuki116,Oka Kazuyuki117,Okada Nobunaga84,Okada Yohei118,Okano Hiromu119,Okamoto Jun120,Okuda Hiroshi121,Ogura Takayuki122,Onodera Yu123,Oyama Yuhta124,Kainuma Motoshi125,Kako Eisuke126,Kashiura Masahiro42,Kato Hiromi16,Kanaya Akihiro127,Kaneko Tadashi128,Kanehata Keita111,Kano Ken‐ichi129,Kawano Hiroyuki130,Kikutani Kazuya12,Kikuchi Hitoshi131,Kido Takahiro132,Kimura Sho68,Koami Hiroyuki133,Kobashi Daisuke111,Saiki Iwao62,Sakai Masahito134,Sakamoto Ayaka135,Sato Tetsuya109,Shiga Yasuhiro136,Shimoto Manabu118,Shimoyama Shinya137,Shoko Tomohisa138,Sugawara Yoh139,Sugita Atsunori140,Suzuki Satoshi141,Suzuki Yuji16,Suhara Tomohiro142,Sonota Kenji143,Takauji Shuhei144,Takashima Kohei46,Takahashi Sho145,Takahashi Yoko146,Takeshita Jun147,Tanaka Yuuki148,Tampo Akihito144,Tsunoyama Taichiro149,Tetsuhara Kenichi150,Tokunaga Kentaro151,Tomioka Yoshihiro152,Tomita Kentaro153,Tominaga Naoki101,Toyosaki Mitsunobu91,Toyoda Yukitoshi154,Naito Hiromichi155,Nagata Isao156,Nagato Tadashi157,Nakamura Yoshimi158,Nakamori Yuki95,Nahara Isao159,Naraba Hiromu73,Narita Chihiro160,Nishioka Norihiro161,Nishimura Tomoya111,Nishiyama Kei162,Nomura Tomohisa163,Haga Taiki164,Hagiwara Yoshihiro165,Hashimoto Katsuhiko166,Hatachi Takeshi49,Hamasaki Toshiaki167,Hayashi Takuya68,Hayashi Minoru129,Hayamizu Atsuki168,Haraguchi Go169,Hirano Yohei29,Fujii Ryo170,Fujita Motoki14,Fujimura Naoyuki171,Funakoshi Hiraku76,Horiguchi Masahito172,Maki Jun173,Masunaga Naohisa174,Matsumura Yosuke175,Mayumi Takuya176,Minami Keisuke177,Miyazaki Yuya178,Miyamoto Kazuyuki179,Murata Teppei180,Yanai Machi181,Yano Takao182,Yamada Kohei183,Yamada Naoki184,Yamamoto Tomonori4,Yoshihiro Shodai185,Tanaka Hiroshi29,Nishida Osamu3

Affiliation:

1. Division of Anesthesiology Department of Surgery Related Kobe University Graduate School of Medicine Kobe Japan

2. Department of Traumatology and Acute Critical Medicine Osaka University Medical School Suita Japan

3. Department of Anesthesiology and Critical Care Medicine Fujita Health University School of Medicine Toyoake Japan

4. Department of Intensive Care Unit Nara Prefectural General Medical Center Nara Japan

5. Department of Disaster and Emergency Medicine Kobe University Graduate School of Medicine Kobe Japan

6. Department of Emergency and Disaster Medicine Juntendo University Tokyo Japan

7. Department of Emergency and Intensive Care Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan

8. Department of Pediatric Critical Care Shizuoka Children's Hospital Shizuoka Japan

9. Division of Emergency and Critical Care Medicine Tohoku University Graduate School of Medicine Sendai Japan

10. Department of Emergency, Disaster, and Critical Care Medicine Faculty of Medicine Kagawa University Kagawa Japan

11. Division of Disaster and Emergency Medicine Department of Surgery Related Kobe University Graduate School of Medicine Kobe Japan

12. Department of Emergency and Critical Care Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

13. Department of Anesthesiology and Intensive Care Medicine Kanazawa University Kanazawa Japan

14. Acute and General Medicine Yamaguchi University Graduate School of Medicine Ube Japan

15. Department of Acute Medicine The University of Tokyo Tokyo Japan

16. Department of Anesthesiology and Intensive Care Medicine Hamamatsu University School of Medicine Hamamatsu Japan

17. Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine Chiba Japan

18. Department of Emergency and Critical Care Medicine Yamagata University Hospital Yamagata Japan

19. Center for General Medicine Education Keio University School of Medicine Tokyo Japan

20. Department of Infectious Diseases Kameda Medical Center Kamogawa Japan

21. Department of Intensive Care Medicine Sapporo Medical University School of Medicine Sapporo Japan

22. Department of Advancing Acute Medicine Graduate School of Medical Sciences Nagoya City University Nagoya Japan

23. Department of Emergency and Critical Care Medicine Nagoya University Graduate School of Medicine Nagoya Japan

24. Department of Emergency Medicine Osaka Medical College Osaka Japan

25. Department of Emergency and Intensive Care Medicine JA Hiroshima General Hospital Hatsukaichi Japan

26. Member of Japanese Association for Acute Medicine Tokyo Japan

27. Division of Trauma and Surgical Critical Care Osaka General Medical Center Osaka Japan

28. Department of Nursing Fujita Health University Hospital Toyoake Japan

29. Department of Emergency and Critical Care Medicine Juntendo University Urayasu Hospital Urayasu Japan

30. Department of Emergency and Critical Care Medicine St. Marianna University School of Medicine Yokohama City Seibu Hospital Yokohama Japan

31. Division of Rehabilitation Department of Clinical Support and Practice Hiroshima University Hospital Hiroshima Japan

32. Department of Anesthesia Kyoto University Hospital Kyoto Japan

33. Department of Psychiatry School of Medicine National Defense Medical College Tokorozawa Japan

34. Curtin University Perth Australia

35. Department of Emergency and Critical Care Medicine/Infectious Disease Hitachi General Hospital Hitachi Japan

36. The Feinstein Institute for Medical Research NY USA

37. Department of Emergency and Critical Care Medicine St. Luke's International Hospital Tokyo Japan

38. Emergency and Critical Care Medical Center Osaka Police Hospital Osaka Japan

39. Department of Emergency and Critical Care Medicine Graduate School of Medicine University of the Ryukyus Okinawa Japan

40. Intensive Care Unit Jikei University Hospital Tokyo Japan

41. The Royal Children's Hospital Melbourne, Melbourne Australia

42. Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center Saitama Japan

43. Department of Emergency and Critical Care Medicine Tsukuba Memorial Hospital Tsukuba Japan

44. Division of Anesthesiology Division of Intensive Care Division of Emergency and Critical Care Sendai City Hospital Sendai Japan

45. Department of Physical Therapy School of Health Sciences Toyohashi Sozo University Toyohashi Japan

46. Critical Care Medicine National Center for Child Health and Development Tokyo Japan

47. Department of General Pediatrics Aichi Children's Health and Medical Center Obu Japan

48. Department of Infectious Disease Hyogo Prefectural Amagasaki General Medical Center Amagasaki Japan

49. Department of Intensive Care Medicine Osaka Women's and Children's Hospital Izumi Japan

50. Human Health Science Graduate School of Medicine Kyoto University Kyoto Japan

51. Department of Acute and Critical Care Nursing School of Nursing Sapporo City University Sapporo Japan

52. Department of Pharmacoepidemiology Kyoto University Graduate School of Medicine and Public Health Kyoto Japan

53. College of Nursing Ibaraki Christian University Hitachi Japan

54. Department of Emergency and Critical Care Medicine Komaki City Hospital Komaki Japan

55. Gastroenterological Center Shinkuki General Hospital Kuki Japan

56. Department of Surgery Okinawa Chubu Hospital Uruma Japan

57. CHU Sainte Justines University of Montreal Montreal Canada

58. Department of Rehabilitation Showa General Hospital Tokyo Japan

59. Department of Emergency Medicine Department of Infectious Diseases Japanese Red Cross Wakayama Medical Center Wakayama Japan

60. Department of Anesthesiology and Intensive Care Medicine International University of Health and Welfare School of Medicine Narita Japan

61. Department of Anesthesiology Tokai University School of Medicine Isehara Japan

62. Department of Anesthesiology Tokyo Medical University Tokyo Japan

63. Division of Intensive Care Nagasaki University Hospital Nagasaki Japan

64. Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE) Fukushima Medical University Fukushima Japan

65. Department of Cardiology Steel Memorial Muroran Hospital Muroran Japan

66. Department of Emergency and Critical Care Medicine Nippon Medical School Musashi Kosugi Hospital Kawasaki Japan

67. Nagasaki University Hospital Acute and Critical Care Center Nagasaki Japan

68. Division of Critical Care Medicine Saitama Children's Medical Center Saitama Japan

69. Department of Emergency and Critical Care Medicine National Hospital Organization Mito Medical Center Ibaraki Japan

70. Department of Emergency and Critical Care Medicine St. Marianna University School of Medicine Kawasaki Japan

71. Department of Intensive Care Medicine Kobe University Hospital Kobe Japan

72. School of Medicine Tokai University Isehara Japan

73. Department of Emergency and Critical Care Medicine Hitachi General Hospital Hitachi Japan

74. Department of Traumatology and Critical Care Medicine Osaka City University Graduate School of Medicine Osaka Japan

75. Division of Intensive Care Department of Anesthesiology and Intensive Care Medicine Jichi Medical University School of Medicine Shimotsuke Japan

76. Department of Emergency and Critical Care Medicine Tokyo Bay Urayasu Ichikawa Medical Center Urayasu Japan

77. Department of Anesthesiology and Intensive Care Medicine Kyoto Prefectural University of Medicine Kyoto Japan

78. Department of Emergency and Critical Care Medicine National Hospital Organization Tokyo Medical Center Tokyo Japan

79. Department of Pharmacy Yokohama Rosai Hospital Yokohama Japan

80. Department of Anesthesiology and Nutrition Support Team Kobe City Medical Center General Hospital Kobe City Hospital Organization Kobe Japan

81. Department of Anesthesiology Kobe University Hospital Kobe Japan

82. Department of Rehabilitation University of Tsukuba Hospital/Exult Co., Ltd Tsukuba Japan

83. Doctoral program in Clinical Sciences. Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan

84. Department of Emergency Medicine Kyoto Prefectural University of Medicine Kyoto Japan

85. Department of Clinical Engineering Osaka University Hospital Suita Japan

86. Department of Intensive Care Medicine Showa University School of Medicine Tokyo Japan

87. Department of Clinical Engineering Kakogawa Central City Hospital Kakogawa Japan

88. Division of Respiratory Care and Rapid Response System Intensive Care Center Kitasato University Hospital Sagamihara Japan

89. Department of Nursing Toho University Omori Medical Center Tokyo Japan

90. Department of Primary Care and Emergency Medicine Kyoto University Hospital Kyoto Japan

91. Department of Emergency and Critical Care Medicine Keio University School of Medicine Tokyo Japan

92. Department of Anesthesiology and Intensive Care Medicine Osaka University Graduate School of Medicine Suita Japan

93. Nursing Department Osaka General Medical Center Osaka Japan

94. Toho University Omori Medical Center Tokyo Japan

95. Department of Clinical Anesthesiology Mie University Hospital Tsu Japan

96. Division of Acute and Critical Care Medicine Department of Anesthesiology and Critical Care Medicine Hokkaido University Faculty of MedicineSapporo Japan

97. Department of Emergency and Critical Care Medicine Eastern Chiba Medical Center Togane Japan

98. Department of Emergency Medicine Gunma University Graduate School of Medicine Maebashi Japan

99. Department of Emergency and Critical Care Medicine Nara Medical University Kashihara Japan

100. Department of Anesthesiology and Intensive Care Oita University Hospital Yufu Japan

101. Department of Emergency and Critical Care Medicine Nippon Medical School Hospital Tokyo Japan

102. Department of Anesthesiology and Intensive Care Medicine Graduate School of Medicine Osaka University Suita Japan

103. Department of Anesthesiology, Emergency and Critical Care Medicine Kure Kyosai Hospital Kure Japan

104. Department of General Internal Medicine Soka Municipal Hospital Soka Japan

105. Department of Emergency and Critical Care Medicine Tokyo Metropolitan Children’s Medical Center Tokyo Japan

106. Department of Biomedical Ethics Graduate School of Medicine The University of Tokyo Tokyo Japan

107. Department of Infectious Diseases Rakuwakai Otowa Hospital

108. Department of Health Informatics School of Public Health Kyoto University Kyoto Japan

109. Tohoku University Hospital Emergency Center Sendai Japan

110. Department of Anesthesiology National Hospital Organization Iwakuni Clinical Center Iwakuni Japan

111. Advanced Medical Emergency Department and Critical Care Center Japan Red Cross Maebashi Hospital Maebashi Japan

112. Department of Anesthesiology Kansai Medical University Hirakata Japan

113. Advanced Emergency and Critical Care Center Saitama Red Cross Hospital Saitama Japan

114. Department of Emergency and Critical Care Medicine University of Tsukuba Tsukuba Japan

115. Department of Emergency and Critical Medicine Showa University Fujigaoka Hospital Yokohama Japan

116. Department of Clinical Epidemiology and Health Economics School of Public Health The University of Tokyo Tokyo Japan

117. Shimane Advanced Trauma Center Izumo Japan

118. Department of Primary care and Emergency medicine Kyoto University Graduate School of Medicine Kyoto Japan

119. Department of Anesthesiology Kyorin University School of Medicine Tokyo Japan

120. Department of ER Hashimoto Municipal Hospital Hashimoto Japan

121. Department of Community Medical Supports Tohoku Medical Megabank Organization Tohoku University Sendai Japan

122. Tochigi prefectural Emergency and Critical Care Center Imperial Gift Foundation Saiseikai Utsunomiya Hospital Utsunomiya Japan

123. Department of Anesthesiology Faculty of Medicine Yamagata University Yamagata Japan

124. Dialysis Center Department of Internal Medicine Kichijoji Asahi Hospital Tokyo Japan

125. Anesthesiology, Emergency Medicine, and Intensive Care Division Inazawa Municipal Hospital Inazawa Japan

126. Department of Anesthesiology and Intensive Care Medicine Nagoya‐City University Graduate School of Medical Sciences Nagoya Japan

127. Department of Anesthesiology Sendai Medical Center Sendai Japan

128. Emergency and Critical Care Center Mie University Hospital Tsu Japan

129. Department of Emergency Medicine Fukui Prefectural Hospital Fukui Japan

130. Department of Gastroenterological Surgery Onga Hospital Fukuoka Japan

131. Department of Emergency and Critical Care Medicine Seirei Mikatahara General Hospital Hamamatsu Japan

132. Department of Pediatrics University of Tsukuba Hospital Tsukuba Japan

133. Center for Translational Injury Research University of Texas Health Science Center at Houston Houston USA

134. Department of General Medicine Shintakeo Hospital Takeo Japan

135. Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan

136. Department of Orthopaedic Surgery Center for Advanced Joint Function and Reconstructive Spine Surgery Graduate school of Medicine Chiba University Chiba Japan

137. Department of Pediatric Cardiology and Intensive Care Gunma Children’s Medical Center Shibukawa Japan

138. Department of Emergency and Critical Care Medicine Tokyo Women's Medical University Medical Center East Tokyo Japan

139. Department of Anesthesiology Yokohama City University Yokohama Japan

140. Division of Emergency and Critical Care Medicine Department of Acute Medicine Nihon University School of Medicine Tokyo Japan

141. Department of Intensive Care Okayama University Hospital Okayama Japan

142. Department of Anesthesiology Keio University School of Medicine Tokyo Japan

143. Department of Intensive Care Medicine Miyagi Children's Hospital Sendai Japan

144. Department of Emergency Medicine Asahikawa Medical University Asahikawa Japan

145. Department of Cardiology Fukuyama City Hospital Fukuyama Japan

146. Department of General Internal Medicine Koga General Hospital Koga Japan

147. Department of Anesthesiology Osaka Women's and Children's Hospital Izumi Japan

148. Fukuoka Prefectural Psychiatric Center Dazaifu Hospital Dazaifu Japan

149. Department of Emergency Medicine Teikyo University School of Medicine Tokyo Japan

150. Emergency and Critical Care Center Kyushu University Hospital Fukuoka Japan

151. Department of Intensive Care Medicine Kumamoto University Hospital Kumamoto Japan

152. Department of Anesthesiology and Intensive Care Unit Todachuo General Hospital Toda Japan

153. Department of Pediatrics Keio University School of Medicine Tokyo Japan

154. Department of Emergency and Critical Care Medicine Saiseikai Yokohamashi Tobu Hospital Yokohama Japan

155. Department of Emergency Critical Care, and Disaster Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan

156. Intensive Care Unit Yokohama City Minato Red Cross Hospital Yokohama Japan

157. Department of Respiratory Medicine Tokyo Yamate Medical center Tokyo Japan

158. Department of Emergency and Critical Care Medicine Japanese Red Cross Kyoto Daini Hospital Kyoto Japan

159. Department of Anesthesiology and Critical Care Medicine Nagoya Daini Red Cross Hospital Nagoya Japan

160. Department of Emergency Medicine and Intensive Care Medicine Shizuoka General Hospital Shizuoka Japan

161. Department of Preventive Services Kyoto University Graduate School of Medicine Kyoto Japan

162. Division of Emergency and Critical Care Medicine Niigata University Graduate School of Medical and Dental Science Niigata Japan

163. Department of Emergency and Critical Care Medicine Juntendo University Nerima Hospital Tokyo Japan

164. Department of Pediatric Critical Care Medicine Osaka City General Hospital Osaka Japan

165. Department of Emergency and Critical Care Medicine Saiseikai Utsunomiya Hospital Utsunomiya Japan

166. Research Associate of Minimally Invasive Surgical and Medical Oncology Fukushima Medical University Fukushima Japan

167. Department of Emergency Medicine Japanese Red Cross Society Wakayama Medical Center Wakayama Japan

168. Department of Emergency Medicine Saitama Saiseikai Kurihashi Hospital Kuki Japan

169. Division of Intensive Care Unit Sakakibara Heart Institute Tokyo Japan

170. Department of Emergency Medicine and Critical Care Medicine Tochigi Prefectural Emergency and Critical Care Center Imperial Foundation Saiseikai Utsunomiya Hospital Utsunomiya Japan

171. Department of Anesthesiology St. Mary’s Hospital Our Lady of the Snow Social Medical Corporation Kurume Japan

172. Department of Emergency and Critical Care Medicine Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan

173. Department of Critical Care Medicine Kyushu University Hospital Fukuoka Japan

174. Department of Healthcare Epidemiology School of Public Health in the Graduate School of Medicine Kyoto University Kyoto Japan

175. Department of Intensive Care Chiba Emergency Medical Center Chiba Japan

176. Department of Internal Medicine Kanazawa Municipal Hospital Kanazawa Japan

177. Ishikawa Prefectual Central Hospital Emergency and Critical Care Center Kanazawa Japan

178. Department of Emergency and General Internal Medicine Saiseikai Kawaguchi General Hospital Kawaguchi Japan

179. Department of Emergency and Disaster Medicine Showa University Tokyo Japan

180. Department of Cardiology Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology Tokyo Japan

181. Department of Emergency Medicine Kobe City Medical Center General Hospital Kobe Japan

182. Department of Critical Care and Emergency Medicine Miyazaki Prefectural Nobeoka Hospital Nobeoka Japan

183. Department of Traumatology and Critical Care Medicine National Defense Medical College Tokorozawa Japan

184. Department of Emergency Medicine University of Fukui Hospital Fukui Japan

185. Pharmaceutical Department JA Hiroshima General Hospital Hatsukaichi Japan

Publisher

Wiley

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