Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography/high‐resolution mass spectrometry

Author:

Ishii Hideaki12ORCID,Shibuya Mariko1ORCID,Leung Gary Ngai‐Wa1ORCID,Nozawa Satoshi1ORCID,Yamashita Shozo1,Yamada Masayuki1,Kushiro Asuka3,Kasashima Yoshinori3,Okada Jun4,Kawasaki Kazumi4,Kijima‐Suda Isao1

Affiliation:

1. Drug Analysis Department Laboratory of Racing Chemistry 1731‐2 Tsuruta‐machi, Utsunomiya Tochigi 320‐0851 Japan

2. Department of Pharmaceutical Sciences Tohoku University Hospital 1‐1 Seiryo‐machi, Aoba‐ku Sendai Miyagi 980‐8574 Japan

3. Research Planning & Coordination Division, JRA Equine Research Institute 1400‐4, Shiba, Shimotsuke Tochigi 329‐0412 Japan

4. Veterinarian Section, Equine Department, Japan Racing Association 6‐11‐1 Roppongi, Minato‐ku Tokyo 105‐0003 Japan

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference25 articles.

1. Metabolic modulators of the exercise response: Doping control analysis of an agonist of the peroxisome proliferator‐activated receptor δ (GW501516) and 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR);Pokrywka A;J Physiol Pharmacol,2014

2. AMPK and PPARδ Agonists Are Exercise Mimetics

3. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice

4. International Federation of Horseracing Authorities.International Agreement.https://www.ifhaonline.org/resources/ifAgreement.pdfAccessed May 11 2020.

5. Fédération Équestre Internationale.2020 Equine Prohibited Substances List.https://inside.fei.org/sites/default/files/2020%20Prohibited%20Substances%20List_0.pdfAccessed June 23 2020.

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