The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease-Reference-Cited by-同舟云学术

The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease

Published:2023-11 Issue:11 Volume:13 Page:
ISSN:2001-1326
Container-title:Clinical and Translational Medicine
language:en
Short-container-title:Clinical & Translational Med

Author:

Tyebally Rika¹²,Xue Angli¹³^ORCID,Powell Joseph E.¹²^ORCID

Affiliation:

1. Translational Genomics Garvan Institute of Medical Research, Darlinghurst Sydney New South Wales Australia

2. UNSW Cellular Genomics Futures Institute University of New South Wales, Kingston Sydney New South Wales Australia

3. School of Biomedical Sciences University of New South Wales Sydney New South Wales Australia

Abstract

AbstractComplex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses (eQTL) can pinpoint cell‐type specific candidate disease‐relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell‐type specific genetic regulation, using Crohn's disease as an example.

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ctm2.1474

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