Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain-Reference-Cited by-同舟云学术

Genome‐wide association analysis of COVID‐19 mortality risk in SARS‐CoV‐2 genomes identifies mutation in the SARS‐CoV‐2 spike protein that colocalizes with P.1 of the Brazilian strain

Published:2021-06-22 Issue:7 Volume:45 Page:685-693
ISSN:0741-0395
Container-title:Genetic Epidemiology
language:en
Short-container-title:Genet. Epidemiol.

Author:

Hahn Georg¹^ORCID,Wu Chloe M.²,Lee Sanghun¹³,Lutz Sharon M.¹⁴,Khurana Surender⁵,Baden Lindsey R.⁶,Haneuse Sebastien¹,Qiao Dandi⁷⁸,Hecker Julian⁴⁷,DeMeo Dawn L.⁷⁸,Tanzi Rudolph E.⁹,Choudhary Manish C.⁷,Etemad Behzad⁷,Mohammadi Abbas⁷,Esmaeilzadeh Elmira⁷,Cho Michael H.⁷⁸,Li Jonathan Z.⁷,Randolph Adrienne G.⁷¹⁰,Laird Nan M.¹,Weiss Scott T.⁷⁸,Silverman Edwin K.⁷⁸,Ribbeck Katharina²,Lange Christoph¹⁷⁸

Affiliation:

1. Department of Biostatistics, T.H. Chan School of Public Health Harvard University Boston Massachusetts USA

2. Department of Biological Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA

3. Department of Medical Consilience, Graduate School Dankook University Yongin South Korea

4. PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA

5. Food and Drug Administration Silver Spring Maryland USA

6. Division of Infectious Diseases Brigham and Women's Hospital Boston Massachusetts USA

7. Harvard Medical School Harvard University Boston Massachusetts USA

8. Department of Medicine, Channing Division of Network Medicine Brigham and Women's Hospital Boston Massachusetts USA

9. Genetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology Massachusetts General Hospital Boston MA USA

10. Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Boston Massachusetts USA

Funder

National Heart, Lung, and Blood Institute

NIH Clinical Center

National Human Genome Research Institute

Publisher

Wiley

Subject

Genetics(clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/gepi.22421

Reference35 articles.

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4. Centers for Disease Control and Prevention. (2021).SARS‐CoV‐2 variant classifications and definitions.https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveillance/variant-info.html

5. Model‐based evaluation of transmissibility and reinfection for the P.1 variant of the SARS‐CoV‐2;Coutinho R. M.;MedRxiv,2021

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