Maternal risk factors for the VACTERL association: A EUROCAT case–control study

Author:

Putte Romy1,Rooij Iris A.L.M.12,Haanappel Cynthia P.1,Marcelis Carlo L.M.3,Brunner Han G.34,Addor Marie‐Claude5,Cavero‐Carbonell Clara6,Dias Carlos M.7,Draper Elizabeth S.8,Etxebarriarteun Larraitz9,Gatt Miriam10,Khoshnood Babak11,Kinsner‐Ovaskainen Agnieszka12,Klungsoyr Kari1314,Kurinczuk Jenny J.15,Latos‐Bielenska Anna16,Luyt Karen17,O'Mahony Mary T.18,Miller Nicola19,Mullaney Carmel20,Nelen Vera21,Neville Amanda J.22,Perthus Isabelle23,Pierini Anna24,Randrianaivo Hanitra25,Rankin Judith26,Rissmann Anke27ORCID,Rouget Florence28,Schaub Bruno29,Tucker David30,Wellesley Diana31,Wiesel Awi32ORCID,Zymak‐Zakutnia Natalya33,Loane Maria34,Barisic Ingeborg35,Walle Hermien E.K.36,Bergman Jorieke E.H.36ORCID,Roeleveld Nel1

Affiliation:

1. Department for Health Evidence, Radboud Institute for Health Sciences Radboud university medical center (Radboudumc) Nijmegen The Netherlands

2. Paediatric Surgery Radboudumc Amalia Children's Hospital Nijmegen The Netherlands

3. Department of Human Genetics Nijmegen The Netherlands

4. Department of Clinical Genetics and School for Oncology & Developmental Biology (GROW) Maastricht University Medical Center Maastricht The Netherlands

5. Department of Woman‐Mother‐Child University Medical Center CHUV Lausanne Switzerland

6. Rare Diseases Research Unit Foundation for the Promotion of Health and Biomedical Research in the Valencian Region Valencia Spain

7. Epidemiology Department National Institute of Health Doutor Ricardo Jorge Lisbon Portugal

8. Department of Health Sciences University of Leicester Leicester UK

9. Department of Health, Public Health Service Basque Government Basque Country Vitoria‐Gasteiz Spain

10. Malta Congenital Anomalies Register Directorate for Health Information and Research Pietà Malta

11. INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), DHU Risks in Pregnancy Paris Descartes University Paris France

12. European Commission, Joint Research Centre (JRC) Ispra Italy

13. Department of Global Public Health and Primary Care University of Bergen Bergen Norway

14. Division for Mental and Physical Health Norwegian Institute of Public Health Bergen Norway

15. National Perinatal Epidemiology Unit, Nuffield Department of Population Health University of Oxford Oxford UK

16. Department of Medical Genetics University of Medical Sciences Poznań Poland

17. South West Congenital Anomaly Register (SWCAR), Bristol Medical School University of Bristol Bristol UK

18. Department of Public Health Health Service Executive – South Cork Ireland

19. National Congenital Anomaly and Rare Disease Registration Service Public Health England Newcastle upon Tyne UK

20. Department of Public Health Health Service Executive – South East Kilkenny Ireland

21. Provinciaal Instituut voor Hygiene (PIH) Antwerp Belgium

22. Registro IMER ‐ IMER Registry (Emilia Romagna Registry of Birth Defects), Center for Clinical and Epidemiological Research University of Ferrara, Azienda Ospedaliero‐Universitaria di Ferrara Ferrara Italy

23. Auvergne registry of congenital anomalies (CEMC‐Auvergne), Department of clinical genetics, Centre de Référence des Maladies Rares University Hospital of Clermont‐Ferrand Clermont‐Ferrand France

24. Tuscany Registry of Congenital Defects (RTDC) Institute of Clinical Physiology ‐ National Research Council / Fondazione Toscana Gabriele Monasterio Pisa Italy

25. Register of congenital malformations of Reunion Island CHU Réunion St Pierre France

26. Institute of Health & Society Newcastle University Newcastle UK

27. Malformation Monitoring Centre Saxony‐Anhalt Medical Faculty Otto‐von‐Guericke University Magdeburg Germany

28. Brittany Registry of congenital anomalies CHU Rennes, University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) Rennes France

29. French West Indies Registry, Registre des Malformations des Antilles (REMALAN), Maison de la Femme de la Mère et de l'Enfant University Hospital of Martinique Fort‐de‐France France

30. CARIS, Public Health Wales Singleton Hospital Swansea UK

31. Wessex Clinical Genetics Department Princess Anne Hospital Southampton UK

32. Department of Pediatrics, Birth Registry Mainz Model University Medical Center of Mainz Mainz Germany

33. OMNI‐Net Ukraine Birth Defects Program and Khmelnytsky City Children's Hospital Khmelnytsky Ukraine

34. Centre for Maternal, Fetal and lnfant Research, lnstitute of Nursing and Health Research Ulster University Belfast UK

35. Centre of Excellence for Reproductive and Regenerative Medicine, Children's Hospital Zagreb Medical School University of Zagreb Zagreb Croatia

36. Department of Genetics, EUROCAT Northern Netherlands University of Groningen, University Medical Center Groningen Groningen The Netherlands

Funder

Radboud Universitair Medisch Centrum

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Developmental Biology,Toxicology,Embryology,Pediatrics, Perinatology and Child Health

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