The type‐I interferon response potentiates seeded tau aggregation and exacerbates tau pathology

Abstract

AbstractINTRODUCTIONSignatures of a type‐I interferon (IFN‐I) response are observed in the post mortem brain in Alzheimer's disease (AD) and other tauopathies. However, the effect of the IFN‐I response on pathological tau accumulation remains unclear.METHODSWe examined the effects of IFN‐I signaling in primary neural culture models of seeded tau aggregation and P301S‐tau transgenic mouse models in the context of genetic deletion of the IFN‐I receptor (IFNAR).RESULTSPolyinosinic:polycytidylic acid (PolyI:C), a synthetic analog of viral nucleic acids, evoked a potent cytokine response that enhanced seeded aggregation of tau in an IFN‐I‐dependent manner. IFN‐I‐induced vulnerability could be pharmacologically prevented and was intrinsic to neurons. Aged P301S‐tau mice lacking Ifnar1 had significantly reduced tau pathology compared to mice with intact IFN signaling.DISCUSSIONWe identify a critical role for IFN‐I in potentiating tau aggregation. IFN‐I is therefore identified as a potential therapeutic target in AD and other tauopathies.Highlights Type‐I IFN (IFN‐I) promotes seeded tau aggregation in neural cultures. IFNAR inhibition prevents IFN‐I driven sensitivity to tau aggregation. IFN‐I driven vulnerability is intrinsic to neurons. Tau pathology is significantly reduced in aged P301S‐tau mice lacking IFNAR.