Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART: a retrospective analysis of South African adult patients on second‐line ART

Author:

Hermans Lucas E123ORCID,Steegen Kim45,Heine Rob6,Schuurman Rob1,Tempelman Hugo A23,Moraba Robert3,Maarseveen Erik7,Nijhuis Monique123,Pillay Taryn89,Legg‐E’Silva Derryn89,Snyman Tracy89,Schapiro Jonathan M10,Burger David M6,Carmona Sergio45,Wensing Annemarie MJ123ORCID

Affiliation:

1. Virology Department of Medical Microbiology University Medical Center Utrecht (UMCU) Utrecht The Netherlands

2. Wits Reproductive Health and HIV Institute (Wits RHI) University of the Witwatersrand Johannesburg South Africa

3. Ndlovu Research Consortium Elandsdoorn South Africa

4. Department of Molecular Medicine and Haematology Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa

5. Department of Molecular Medicine and Haematology National Health Laboratory Service (NHLS) Johannesburg South Africa

6. Department of Pharmacy Radboud Institute for Health Sciences Radboud University Medical Center Nijmegen The Netherlands

7. Clinical Pharmacology UMCU The Netherlands

8. Department of Chemistry University of the Witwatersrand Johannesburg South Africa

9. National Health Laboratory Service (NHLS) Johannesburg South Africa

10. National Hemophilia Center Sheba Medical Center Ramat Gan Israel

Funder

The Netherlands Organisation for Health Research and Development (ZonMW) and NWO-WOTRO Science for Global Development

Publisher

Wiley

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference38 articles.

1. Long-term Virological Outcomes of First-Line Antiretroviral Therapy for HIV-1 in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis

2. Virological suppression and clinical management in response to viremia in South African HIV treatment program: A multicenter cohort study

3. World Health Organization.Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection.2016. Available from:https://www.who.int/hiv/pub/arv/arv‐2016/en/. Accessed May 10 2020.

4. Clinton Health Access Initiative. HIV Market Report.2019. Available from:https://3cdmh310dov3470e6x160esb‐wpengine.netdna‐ssl.com/wp‐content/uploads/2019/12/2019‐HIVMarket‐Report.pdf. Accessed May 10 2020.

5. Sustained Virological Response on Second-Line Antiretroviral Therapy following Virological Failure in HIV-Infected Patients in Rural South Africa

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