Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network

Author:

Frezza Anna Maria1ORCID,Assi Tarek2,Lo Vullo Salvatore3ORCID,Ben‐Ami Eytan4ORCID,Dufresne Armelle5,Yonemori Kan6,Noguchi Emi6,Siontis Brittany7,Ferraro Richard8,Teterycz Pawel9,Duffaud Florence10,Ravi Vinod11,Vincenzi Bruno12,Gelderblom Hans13,Pantaleo Maria A.14,Baldi Giacomo G.15,Desar Ingrid16,Fedenko Alexander17,Maki Robert G.18,Jones Robin L.19,Benjamin Robert S.11,Blay Jean Yves5ORCID,Kawai Akira6ORCID,Gounder Mrinal8,Gronchi Alessandro20,Le Cesne Axel2,Mir Olivier2,Czarnecka Anna M.9,Schuetze Scott7,Wagner Andrew J.4ORCID,Adam Julien21,Barisella Marta22,Sbaraglia Marta23,Hornick Jason L.24,Meurgey Alexandra25,Mariani Luigi3,Casali Paolo G.126,Thornton Katherine4,Stacchiotti Silvia1ORCID

Affiliation:

1. Department of Medical Oncology IRCCS Fondazione Istituto Nazionale Tumori Milan Italy

2. Department of Cancer Medicine Gustave Roussy Cancer Campus Villejuif France

3. Unit of Clinical Epidemiology and Trial Organization IRCCS Fondazione Istituto Nazionale Tumori Milan Italy

4. Center for Sarcoma and Bone Oncology Dana‐Farber Cancer Institute Boston Massachusetts

5. Department of Medical Oncology Centre Léon Bérard & Université Claude Bernard Lyon I Lyon France

6. Department of Musculoskeletal Oncology National Cancer Center Hospital Tokyo Japan

7. Department of Medicine University of Michigan Ann Arbor Michigan

8. Department of Medicine Sarcoma Medical Oncology Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York New York

9. Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska‐Curie Institute‐Oncology Center Warsaw Poland

10. Department of Medical Oncology La Timone University Hospital Aix‐Marseille Université Marseille France

11. Department of Sarcoma Medical Oncology The University of Texas MD Anderson Cancer Center Houston Texas

12. Department of Medical Oncology Università Campus Bio‐Medico di Roma Rome Italy

13. Department of Medical Oncology Leiden University Medical Center Leiden Netherlands

14. Department of Specialized, Experimental and Diagnostic Medicine S. Orsola‐Malpighi Hospital University of Bologna Bologna Italy

15. Department of Medical Oncology Nuovo Ospedale “S. Stefano,” Prato Italy

16. Department of Medical Oncology Radboud University Medical Center Nijmegen the Netherlands

17. Department of Medical Oncology N. N. Blokhin Russian Cancer Research Moscow Russian Federation

18. Medical Oncology Northwell Cancer Institute and Cold Spring Harbor Laboratory Long Island New York

19. Sarcoma Unit Royal Marsden NHS Foundation Trust/Institute of Cancer Research London United Kingdom

20. Sarcoma Surgery Fondazione IRCCS Istituto Nazionale dei Tumori Milano Italy

21. Department of Pathology Gustave Roussy Cancer Campus Villejuif France

22. Department of Diagnostic Pathology and Laboratory Medicine IRCCS Fondazione Istituto Nazionale dei Tumori Milan Italy

23. Department of Pathology Treviso Regional Hospital Italy

24. Department of Pathology Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts

25. Department of Biopathology Centre Léon Bérard Lyon France

26. Department of Oncology and Hemato‐oncology University of Milan Milan Italy

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference14 articles.

1. Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas;Neuville A;Am J Surg Pathol,2014

2. Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery

3. Single-Center Experience with Intimal Sarcoma, an Ultra-Orphan, Commonly Fatal Mesenchymal Malignancy

4. Primary aortic intimal sarcoma

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