Naturally evolvable antibody affinity may be physically limited
Author:
Affiliation:
1. Department of Physics and Astronomy University of California, Los Angeles Los Angeles California USA
Publisher
Wiley
Subject
General Biochemistry, Genetics and Molecular Biology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.202100045
Reference5 articles.
1. Germinal Centers
2. Kinetic and affinity limits on antibodies produced during immune responses.
3. Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-Rate
4. Physical ‘strength’ of the multi‐protein chain connecting immune cells: Does the weakest link limit antibody affinity maturation?
5. B Cells Use Mechanical Energy to Discriminate Antigen Affinities
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