Synthesis and molecular docking of novel fluorescent alkoxy‐substituted iodobiphenyl analogues

Abstract

AbstractNew fluorescent iodobiphenyl ethers bearing para‐alkyloxy functional groups of diverse alkyl tail lengths were synthesized. The synthesis process was simply accomplished via an alkali‐assisted reaction of aliphatic alcohols with hydroxyl‐substituted iodobiphenyls. The molecular structures of the prepared iodobiphenyl ethers were determined using Fourier transform infrared (FTIR) spectroscopy, elemental analysis, and nuclear magnetic resonance (NMR) spectroscopy. Both absorption and fluorescence spectra proved solvatochromic activity. The synthesized alkyloxy‐substituted iodobiphenyl analogues were tested for antioxidant effectiveness using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) methodology. The antioxidant outcomes demonstrated that the longest hydrocarbon chain‐containing substituted iodobiphenyl analogues had a high efficacy with over an IC50 = 21.26 ± 0.36 μg/ml. Alkyloxy‐substituted iodobiphenyl analogues also underwent docking operations over the 5IKQ protein.