Building efficient comparative effectiveness trials through adaptive designs, utility functions, and accrual rate optimization: finding the sweet spot

Author:

Gajewski Byron J.1ORCID,Berry Scott M.2,Quintana Melanie2,Pasnoor Mamatha3,Dimachkie Mazen3,Herbelin Laura3,Barohn Richard3

Affiliation:

1. Department of Biostatistics; University of Kansas Medical Center; Kansas City 66160 KS U.S.A.

2. Berry Consultants; 4301 Westbank Drive, Suite 140, Bldg B Austin 78746 TX U.S.A.

3. Department of Neurology; University of Kansas Medical Center; Kansas City 66160 KS U.S.A.

Funder

National Center for Advancing Translational Sciences

Patient-Centered Outcomes Research Institute

Leonard Wilk Trust

Publisher

Wiley

Subject

Statistics and Probability,Epidemiology

Reference22 articles.

1. Bayesian adaptive clinical trials: a dream for statisticians only?;Chevret;Statistics in Medicine,2012

2. A guide to drug discovery: Bayesian clinical trials (2006);Berry;Nature Reviews Drug Discovery,2006

3. Adaptive clinical trials in oncology;Berry;Nature Reviews Clinical Oncology,2012

4. Bayesian clinical trials in action;Lee;Statistics in Medicine,2012

5. Bayesian approaches in medical device clinical trials: a discussion with examples in the regulatory setting;Bonangelino;Journal of Biopharmaceutical Statistics,2011

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