The N‐terminal segment of antithrombin acts as a steric gate for the binding of heparin
Author:
Affiliation:
1. Department of Haematology, University of Cambridge, MRC Centre, Hills Road, Cambridge, CB22QH, United Kingdom
Funder
University of Cambridge
Wellcome Trust
British Heart Foundation
Medical Research Council
Publisher
Wiley
Subject
Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.5560070328
Reference20 articles.
1. Antithrombin Rouen-IV 24 Arg→Cys The amino-terminal contribution to heparin binding
2. Biological implications of a 3 å structure of dimeric antithrombin
3. Antithrombin III Basel. Identification of a Pro-Leu substitution in a hereditary abnormal antithrombin with impaired heparin cofactor activity.
4. Probing serpin reactive-loop conformations by proteolytic cleavage
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