SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR

Author:

Song Jingjing12,Liu Yupeng12,Wan Juan3,Zhao Guang‐Nian4,Wang Jian‐Cheng5,Dai Zhifei6,Hu Sha3,Yang Ling3,Liu Zhen3,Fu Yi7,Dong Erdan89,Tang Yi‐Da129

Affiliation:

1. Department of Cardiology State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing China

2. Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

3. Department of Cardiology Renmin Hospital of Wuhan University Wuhan China

4. Medical Science Research Center Zhongnan Hospital of Wuhan University Wuhan China

5. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China

6. Department of Biomedical Engineering College of Future Technology Peking University Beijing China

7. Department of Physiology and Pathophysiology School of Basic Medical Sciences Peking University Health Science CenterKey Laboratory of Molecular Cardiovascular Science, Ministry of Education Beijing China

8. The Institute of Cardiovascular Sciences Peking UniversityNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing Key Laboratory of Cardiovascular Receptors Research Beijing China

9. Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalKey Laboratory of Molecular Cardiovascular Science, Ministry of Education Beijing China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Publisher

Wiley

Subject

Hepatology

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