Serum leucine‐rich α2‐glycoprotein as a possible marker for inflammatory status in endometriosis

Author:

Kobayashi Mio1,Nakamura Orie1,Kitahara Yoshikazu1ORCID,Inoue Naoki1,Tsukui Yumiko1,Hasegawa Yuko1,Hiraishi Hikaru1,Yabuki Atsushi2,Muraoka Ayako2,Osuka Satoko2ORCID,Iwase Akira1ORCID

Affiliation:

1. Department of Obstetrics and Gynecology Gunma University Graduate School of Medicine Maebashi Japan

2. Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Abstract

AbstractPurposeThis study aimed to investigate whether serum leucine‐rich α2‐glycoprotein (LRG) is a useful diagnostic biomarker for endometriosis, including the evaluation of treatment efficacy and exploration of LRG production in endometriotic lesions.MethodsForty‐three women with endometriomas were compared to 22 women with benign ovarian cysts and 30 women who underwent assisted reproduction as controls. Changes in serum LRG levels were assessed before and after surgery, and during dienogest treatment. LRG expression in endometriotic tissue samples was evaluated using immunoblotting.ResultsSerum LRG levels in the endometrioma group (80.0 ± 36.3 μg/mL) were significantly higher than those in the benign ovarian cyst (65.1 ± 27.0 μg/mL, p = 0.0265) and control (57.8 ± 22.3 μg/mL, p = 0.0028) groups. Serum LRG levels after endometrioma surgery were significantly lower than preoperative levels (p = 0.0484). Serum LRG levels consistently decreased during dienogest treatment. LRG expression levels were significantly higher in endometriotic tissues than in the normal endometrium.ConclusionSerum LRG, possibly derived from local and systemic origins, could be used as a potential biomarker for the diagnosis and treatment of endometriosis.

Funder

Bayer

Publisher

Wiley

Subject

Cell Biology,Reproductive Medicine

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