Affiliation:
1. NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha Hunan China
2. School of Medicine Hunan Normal University Changsha Hunan China
3. Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITIC‐Xiangya Changsha Hunan China
4. National Engineering and Research Center of Human Stem Cells Changsha Hunan China
Abstract
AbstractPurposeTo explore whether spermatozoa from AZFc microdeletion patients affect their outcomes of intracytoplasmic sperm injection (ICSI).MethodsEighty‐five patients with AZFc microdeletion were recruited. A control group of one hundred and forty patients with severe oligozoospermia but without AZF microdeletion was selected using propensity score matching analysis with a 1:2 nearest neighbor algorithm ratio. The ICSI outcomes of the two groups were compared.ResultsAZFc microdeletion had lower rates of normal fertilization (73% vs. 80%, p = 0.17) and high‐quality embryos (44% vs. 58%, p = 0.07) than the control group. There was no significant difference in the clinical pregnancy rate, miscarriage rate, and live birth rate between the two groups. When the sperm concentration was <1 million/mL, the AZFc microdeletion group exhibited lower rates of fertilization (71% vs. 80%, p = 0.03), high‐quality embryo (44% vs. 58%, p = 0.02), clinical pregnancy (57% vs. 76%, p = 0.02), and live birth (49% vs. 72%, p = 0.01) than the control group. However, if sperm concentration was ≥1 million/mL, no significant differences were found.ConclusionIf the sperm concentration is <1 million/mL, AZFc microdeletion do have a detrimental effect on most outcomes of ICSI.
Funder
National Natural Science Foundation of China