Computational Modelling of Dapsone Interaction With Dihydropteroate Synthase inMycobacterium leprae; Insights Into Molecular Basis of Dapsone Resistance in Leprosy-Reference-Cited by-同舟云学术

Computational Modelling of Dapsone Interaction With Dihydropteroate Synthase inMycobacterium leprae; Insights Into Molecular Basis of Dapsone Resistance in Leprosy

Published:2015-08-14 Issue:10 Volume:116 Page:2293-2303
ISSN:0730-2312
Container-title:Journal of Cellular Biochemistry
language:en
Short-container-title:J. Cell. Biochem.

Author:

Chaitanya Sundeep¹,Das Madhusmita¹,Bhat Pritesh²,Ebenezer Mannam³

Affiliation:

1. Research Officer; Department of Laboratories; Molecular Biology and Immunology Division; The Schieffelin Institute of Health-Research and Leprosy Center (SIH-R&LC); Karigiri; Vellore Tamil Nadu 632106 India

2. Applications Scientist; Schrodinger, Inc.; Near KMWA Vidya Niketan; Mahalakshmipuram; Bangalore 560 086 India

3. The Schieffelin Institute of Health-Research and Leprosy Center (SIH-R&LC); Karigiri; Vellore Tamil Nadu 632106 India

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jcb.25180/fullpdf

Reference43 articles.

1. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: New insight into the enzymatic mechanism and sulfa-drug action;Baca;J Mol Biol,2000

2. Applying physics-based scoring to calculate free energies of binding for single amino acid mutations in protein-protein complexes;Beard;PloS ONE,2013

3. Rifampin in the treatment of leprosy;Bullock;Rev Infect Dis,1983