Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions-Reference-Cited by-同舟云学术

Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions

Published:2020-12-31 Issue:3 Volume:39 Page:266-279
ISSN:1066-5099
Container-title:Stem Cells
language:en
Short-container-title:

Author:

Oh Eun Jung¹,Gangadaran Prakash²³,Rajendran Ramya Lakshmi²,Kim Hyun Mi¹^ORCID,Oh Ji Min²,Choi Kang Young¹,Chung Ho Yun¹³,Ahn Byeong-Cheol²³⁴^ORCID

Affiliation:

1. Department of Plastic and Reconstructive Surgery, CMRI, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea

2. Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

3. BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

4. Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea

Abstract

Abstract Extracellular vesicles (EVs) have been exhibited as promising candidates for delivering endogenous therapeutic cargos for regenerative therapies. Fibroblasts could be candidate source cells for EVs, to investigate their therapeutic effects in wound healing. Here we demonstrated the isolation and characterization of fibroblast-derived (L929 cell line) EVs (L929-EVs). Furthermore, L929-EVs treatment showed pro-wound healing effects in vitro by enhancing proliferation, migration, and scarless wound healing related genes in fibroblast cells. L929-EVs treatment also enhanced the migration and tube formation of endothelial cells. The combination of L929-EVs with fibrin glue accelerated wound healing in the mouse skin wound model by enhancing collagen formation, collagen maturation, and blood vessels in the wounded skin. The role of fibroblast-derived EVs in wound healing could be an important phenomenon, and fibroblast-derived EVs could be harnessed for wound healing therapies.

Funder

National Research Foundation of Korea

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/stem.3310

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