Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis

Author:

Hubbard Nicholas A.1,Turner Monroe P.2,Ouyang Minhui34,Himes Lyndahl2,Thomas Binu P.25,Hutchison Joanna L.2,Faghihahmadabadi Shawheen6,Davis Scott L.7,Strain Jeremy F.8,Spence Jeffrey2,Krawczyk Daniel C.29,Huang Hao34,Lu Hanzhang10,Hart John211,Frohman Teresa C.12,Frohman Elliot M.12,Okuda Darin T.11,Rypma Bart29

Affiliation:

1. McGovern Institute for Brain Research; Massachusetts Institute of Technology; Cambridge Massachusetts

2. School of Behavioral and Brain Sciences; University of Texas at Dallas; Richardson Texas

3. Department of Radiology; University of Pennsylvania Perelman School of Medicine; Philadelphia Pennsylvania

4. Children's Hospital of Philadelphia; Philadelphia Pennsylvania

5. Advanced Imaging Research Center; University of Texas Southwestern Medical Center; Dallas Texas

6. Department of Internal Medicine; University of Texas Medical Branch; Galveston Texas

7. Department of Applied Physiology and Wellness; Southern Methodist University; Dallas Texas

8. Department of Neurology; Washington University in St. Louis; St. Louis Missouri

9. Department of Psychiatry; University of Texas Southwestern Medical Center; Dallas Texas

10. Department of Radiology; Johns Hopkins University School of Medicine; Baltimore Maryland

11. Department of Neurology and Neurotherapeutics; University of Texas Southwestern Medical Center; Dallas Texas

12. Department of Neurology; The University of Texas at Austin Dell Medical School; Austin Texas

Funder

National Multiple Sclerosis Society

National Institutes of Health

Publisher

Wiley

Subject

Clinical Neurology,Neurology,Radiology Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Anatomy

Reference102 articles.

1. Latency of multifocal visual evoked potentials in nonoptic neuritis eyes of multiple sclerosis patients associated with optic radiation lesions;Alshowaeir;ARVO,2014

2. Quality of life in multiple sclerosis: The impact of depression, fatigue, and disability;Amato;Mult Scler,2001

3. Regional differences in the coupling of cerebral blood flow and oxygen metabolism changes in response to activation: Implications for BOLD-fMRI;Ances;NeuroImage,2008

4. Glial and neuronal control of brain blood flow;Attwell;Nature,2010

5. Altered functional connectivity related to white matter changes inside the working memory network at the very early stage of MS;Au Duong;JCBFM,2005

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