Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Author:

Litvinchuk Alexandra1ORCID,Huynh Tien‐Phat V.12ORCID,Shi Yang1ORCID,Jackson Rosemary J.3ORCID,Finn Mary B.1,Manis Melissa1,Francis Caroline M.1,Tran Ainsley C.1,Sullivan Patrick M.4ORCID,Ulrich Jason D.1ORCID,Hyman Bradley T.3ORCID,Cole Tracy5,Holtzman David M.1ORCID

Affiliation:

1. Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis MO

2. Medical Scientist Training Program (MSTP) Washington University School of Medicine St. Louis MO

3. Department of Neurology, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease Massachusetts General Hospital Charlestown MA

4. Department of Medicine, Duke University Medical Center, Durham Veterans Health Administration Medical Center's Geriatric Research Education and Clinical Center Durham NC

5. Ionis Pharmaceuticals, Inc. Carlsbad CA

Funder

JPB Foundation

National Institutes of Health

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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