Effects of Hawthorn Flavonoids on Intestinal Microbial Community and Metabolic Phenotype in Obese Rats

Author:

Bi Yu1ORCID,Lv Chang2,Zhu Juanjuan2,Zhou Qiao2,Xu Xiaoxiao1,Yang Shuo1,Shi Dianhua2,Zhou Qian2,Dai Yanpeng2ORCID

Affiliation:

1. Shandong University of Traditional Chinese Medicine No. 4655 University Road Jinan Shandong 250355 China

2. Shandong Academy of Chinese Medicine No.7 Yanzi Shanxi Road, Lixia District Jinan Shandong 250014 China

Abstract

AbstractObesity (OB) is a prevalent metabolic disorder. With the advancement of the economy, the prevention and treatment of obesity is a big problem for the global community. The methods to lose weight include exercise, diet, medicine, and surgery. Compared with other methods, diet regulation is safer and more effective. Hawthorn fruit has the effect of reducing weight, but the mechanism of effectiveness are not clear. In this study, obesity model rats are used to conduct scientific pharmacological research on hawthorn flavonoids. Hawthorn flavonoids can effectively improve the body weight, lipid accumulation, and lipid levels of obese rats. The contents of the colon of rats are analyzed using 16S rDNA sequencing technology. The intestinal microflora in obese rats changed significantly after flavonoids treatment, and they tended to be the control group. Based on liquid chromatography‐mass spectrometry, serum metabolomics showed that the metabolites in the serum changed significantly, after hawthorn flavonoids treatment. Hawthorn flavonoids are especially involved in the biological processes of grade bile acid biosynthesis, histidine metabolism, and lipid metabolism. Pearson correlation analysis showed that the disorder of intestinal microorganisms is connected to changes in serum metabolites. These findings give a new idea about how hawthorn flavonoids help with obesity.

Publisher

Wiley

Subject

General Medicine

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