Affiliation:
1. Department of Shock and Transfusion Research Institute of Surgery State Key Laboratory of Trauma Burns and Combined Injury Daping Hospital Army Medical University Chongqing 400042 P. R. China
2. Department of Weapon Bioeffect Assessment Research Institute of Surgery State Key Laboratory of Trauma Burns and Combined Injury Daping Hospital Army Medical University Chongqing 400042 P. R. China
Abstract
AbstractSevere trauma and hemorrhaging are often accompanied by delayed cutaneous wound healing. Soybean isoflavone is a natural phytoestrogen that has attracted great attention due to its protective effects against various injuries. Endothelial progenitor cells (EPCs) are precursor cells with directional differentiation characteristics. This study is to determine whether genistein (GEN), an isoflavone in soybean products, benefits wound healing in hemorrhagic shock (HS) rats by promoting EPC homing and to investigate the underlying mechanisms. In this study, it is found that GEN promotes skin wound healing in HS rats, which is due at least partly to the mobilization of endogenous EPCs to the injury site via angiotensin II (Ang‐II), stromal cell‐derived factor‐1alpha (SDF‐1α), and transforming growth factor beta(TGF‐β) signaling.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
General Biochemistry, Genetics and Molecular Biology,Biomedical Engineering,Biomaterials
Cited by
6 articles.
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