Progress in The Research of Lactate Metabolism Disruption And Astrocyte‐Neuron Lactate Shuttle Impairment in Schizophrenia: A Comprehensive Review

Author:

Zhang Yingying1ORCID,Tong Liang1,Ma Li1,Ye Hong1,Zeng Shue1,Zhang Shaochuan1,Ding Yu2,Wang Weiwei2,Bao Tianhao1ORCID

Affiliation:

1. Mental Health Centre of Kunming Medical University Kunming Yunnan 650225 P. R. China

2. The Second Affiliated Hospital of Kunming Medical University Kunming Yunnan 650101 P. R. China

Abstract

AbstractSchizophrenia (SCZ) is a complex neuropsychiatric disorder widely recognized for its impaired bioenergy utilization. The astrocyte‐neuron lactate shuttle (ANLS) plays a critical role in brain energy supply. Recent studies have revealed abnormal lactate metabolism in SCZ, which is associated with mitochondrial dysfunction, tissue hypoxia, gastric acid retention, oxidative stress, neuroinflammation, abnormal brain iron metabolism, cerebral white matter hypermetabolic activity, and genetic susceptibility. Furthermore, astrocytes, neurons, and glutamate abnormalities are prevalent in SCZ with abnormal lactate metabolism, which are essential components for maintaining ANLS in the brain. Therefore, an in‐depth study of the pathophysiological mechanisms of ANLS in SCZ with abnormal lactate metabolism will contribute to a better understanding of the pathogenesis of SCZ and provide new ideas and approaches for the diagnosis and treatment of SCZ.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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