Affiliation:
1. Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an 710032 P. R. China
2. The State Laboratory of Cancer Biology Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi'an 710032 P. R. China
Abstract
AbstractProtein degradation is a general process to maintain cell homeostasis. The intracellular protein quality control system mainly includes the ubiquitin‐proteasome system and the lysosome pathway. Inspired by the physiological process, strategies to degrade specific proteins have developed, which emerge as potent and effective tools in biological research and drug discovery. This review focuses on recent advances in targeted protein degradation techniques, summarizing the principles, advantages, and challenges. Moreover, the potential applications and future direction in biological science and clinics are also discussed.
Funder
National Natural Science Foundation of China
Cited by
2 articles.
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