Affiliation:
1. Assisted Reproductive Center Women's & Children's Hospital of Northwest Xi'an Shanxi Province 710000 China
2. University of South Bohemia in Ceske Budejovice Vodnany 38925 Czech Republic
3. Changsha Medical University Changsha Hunan Province 410000 China
4. Medical Center of Hematology the Second Affiliated Hospital Army Medical University Chongqing Sichuan Province 404100 China
Abstract
AbstractAs 3D culture technology advances, new avenues have opened for the development of physiological human cancer models. These preclinical models provide efficient ways to translate basic cancer research into clinical tumor therapies. Recently, cancer organoids have emerged as a model to dissect the more complex tumor microenvironment. Incorporating cancer organoids into preclinical programs have the potential to increase the success rate of oncology drug development and recapitulate the most efficacious treatment regimens for cancer patients. In this review, four main types of cancer organoids are introduced, their applications, advantages, limitations, and prospects are discussed, as well as the recent application of single‐cell RNA‐sequencing (scRNA‐seq) in exploring cancer organoids to advance this field.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shaanxi Province
Fundamental Research Funds for the Central Universities