COVID‐19 Metabolomic‐Guided Amino Acid Therapy Protects from Inflammation and Disease Sequelae

Author:

Ming Siqi12,Qu Siying1,Wu Yongjian1,Wei Jiayou1,Zhang Guoliang2,Jiang Guanmin1,Huang Xi12ORCID

Affiliation:

1. Center for Infection and Immunity and Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai Guangdong Province 519000 China

2. National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital Southern University of Science and Technology Shenzhen Guangdong Province 518100 China

Abstract

AbstractThe outbreak of coronavirus disease 2019 (COVID‐19) has caused a worldwide pandemic since 2019. A metabolic disorder is a contributing factor to deaths from COVID‐19. However, the underlying mechanism of metabolic dysfunction in COVID‐19 patients and the potential interventions are not elucidated. Here targeted plasma metabolomic is performed, and the metabolite profiles among healthy controls, and asymptomatic, moderate, and severe COVID‐19 patients are compared. Among the altered metabolites, arachidonic acid and linolenic acid pathway metabolites are profoundly up‐regulated in COVID‐19 patients. Arginine biosynthesis, alanine, aspartate, and glutamate metabolism pathways are significantly disturbed in asymptomatic patients. In the comparison of metabolite variances among the groups, higher levels of l‐citrulline and l‐glutamine are found in asymptomatic carriers and moderate or severe patients at the remission stage. Furthermore, l‐citrulline and l‐glutamine combination therapy is demonstrated to effectively protect mice from coronavirus infection and endotoxin‐induced sepsis, and is observed to efficiently prevent the occurrence of pulmonary fibrosis and central nervous system damage. Collectively, the data reveal the metabolite profile of asymptomatic COVID‐19 patients and propose a potential strategy for COVID‐19 treatment.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology,Biomedical Engineering,Biomaterials

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