Abstract
Ergotamine preparations are extensively used in the treatment of migraine. Although not widely appreciated, there have been reports in the literature of ergotamine abuse, related to the development of tolerance and withdrawal headaches, which result in a steadily increasing consumption of the drug (Wolfson and Graham, 1949; Peters and Horton, 1951; Friedman et al., 1955). It is important clinically to recognize this condition, as ergotamine can have dangerous vascular side-effects (Byrne-Quinn, 1964; Cranley et al., 1963; Young and Humphries, 1961).
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference19 articles.
1. ‘Impending gangrene of four extremities secondary to ergotism.’;Cran ley;New England Journal of Medicine,1963
2. ‘Headache: with special reference to the excessive use of ergotamine preparations and withdrawal effects.’;Peters;Proceedings of Mayo Clinic,1951
3. ‘Development of tolerance to ergot alkaloids in a patient with unusually severe migraine.’;Wolfson;New England Journal of Mediane,1949
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